Origins of vascular and hematopoietic system.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523250" target="_blank" >RIV/68378050:_____/19:00523250 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Origins of vascular and hematopoietic system.

Popis výsledku v původním jazyce

In all vertebrates examined to date, the primitive vascular network arises from endothelial precursors called angioblasts. Equipotent angioblasts undergo successive steps of differentiation that, along with cues from local microenvironments, give rise to specialized subsets of endothelial cells (ECs), such as arterial, venous, endocardial or blood brain barrier ECs. Another specialized subset of arterial ECs includes hemogenic endothelium. These cells arise from ventral aortic endothelium and they give rise to hematopoietic stem cells that are further responsible for formation of the whole blood forming system. This suggests that endothelial and hematopoietic development is tightly connected. Understanding the molecular mechanisms responsible for the specification of these cell types is crucial to treat vascular and blood diseases.

Název v anglickém jazyce

Origins of vascular and hematopoietic system.

Popis výsledku anglicky

In all vertebrates examined to date, the primitive vascular network arises from endothelial precursors called angioblasts. Equipotent angioblasts undergo successive steps of differentiation that, along with cues from local microenvironments, give rise to specialized subsets of endothelial cells (ECs), such as arterial, venous, endocardial or blood brain barrier ECs. Another specialized subset of arterial ECs includes hemogenic endothelium. These cells arise from ventral aortic endothelium and they give rise to hematopoietic stem cells that are further responsible for formation of the whole blood forming system. This suggests that endothelial and hematopoietic development is tightly connected. Understanding the molecular mechanisms responsible for the specification of these cell types is crucial to treat vascular and blood diseases.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LO1419" target="_blank" >LO1419: Biomodely pro zdraví - Centrum modelových organismů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Disease Models

ISBN

978-80-88011-06-4

Počet stran výsledku

7

Strana od-do

296-302

Počet stran knihy

310

Název nakladatele

OPTIO CZ

Místo vydání

Praha

Kód UT WoS kapitoly

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