Medaka fish as a model in biomedical vision research

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523251" target="_blank" >RIV/68378050:_____/19:00523251 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Medaka fish as a model in biomedical vision research

Popis výsledku v původním jazyce

Medaka (Oryzias latipes) is a small freshwater fish distantly related to the most widely used teleost model organism, zebrafish (Danio rerio). The two teleost fish have become popular models to study various aspects of developmental biology and genetics of the eye. Although the duration of eye development in human, mouse, chick, zebrafish or medaka is vastly different, the sequence of events, the type of embryonic tissues involved and spatiotemporal expression of key regulatory genes is remarkably similar. Medaka mutants constitute a rich resource for studies addressing molecular mechanisms underlying vertebrate eye organogenesis. In addition, recent technological progress, such as implementation of CRISPR/Cas9 approaches, opens up new opportunities for disease modelling. In summary, established state-of-the art molecular and genetic tools make medaka an attractive vertebrate model for future biomedical research, especially as an experimental platform for the development of new clinical tools for the diagnosis and treatment of human disease.

Název v anglickém jazyce

Medaka fish as a model in biomedical vision research

Popis výsledku anglicky

Medaka (Oryzias latipes) is a small freshwater fish distantly related to the most widely used teleost model organism, zebrafish (Danio rerio). The two teleost fish have become popular models to study various aspects of developmental biology and genetics of the eye. Although the duration of eye development in human, mouse, chick, zebrafish or medaka is vastly different, the sequence of events, the type of embryonic tissues involved and spatiotemporal expression of key regulatory genes is remarkably similar. Medaka mutants constitute a rich resource for studies addressing molecular mechanisms underlying vertebrate eye organogenesis. In addition, recent technological progress, such as implementation of CRISPR/Cas9 approaches, opens up new opportunities for disease modelling. In summary, established state-of-the art molecular and genetic tools make medaka an attractive vertebrate model for future biomedical research, especially as an experimental platform for the development of new clinical tools for the diagnosis and treatment of human disease.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LO1419" target="_blank" >LO1419: Biomodely pro zdraví - Centrum modelových organismů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Disease Models

ISBN

978-80-88011-06-4

Počet stran výsledku

8

Strana od-do

303-310

Počet stran knihy

310

Název nakladatele

OPTIO CZ

Místo vydání

Praha

Kód UT WoS kapitoly

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