Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00554554" target="_blank" >RIV/68378050:_____/21:00554554 - isvavai.cz</a>

Výsledek na webu

<a href="https://www-cell-com.d360prx.biomed.cas.cz/trends/genetics/fulltext/S0168-9525(21)00164-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0168952521001645%3Fshowall%3Dtrue" target="_blank" >https://www-cell-com.d360prx.biomed.cas.cz/trends/genetics/fulltext/S0168-9525(21)00164-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0168952521001645%3Fshowall%3Dtrue</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tig.2021.06.008" target="_blank" >10.1016/j.tig.2021.06.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility

Popis výsledku v původním jazyce

Hybrid sterility is a critical step in the evolution of reproductive barriers between diverging taxa during the process of speciation. Recent studies of young subspecies of the house mouse revealed a multigenic nature and frequent polymorphism of hybrid sterility genes as well as the recurrent engagement of the meiosis-specific gene PR domain-containing 9 (Prdm9) and X-linked loci. Prdm9-controlled hybrid sterility is essentially chromosomal in nature, conditioned by the sequence divergence between subspecies. Depending on the Prdm9 interallelic interactions and the X-linked Hstx2 locus, the same homologs either regularly recombine and synapse, or show impaired DNA DSB repair, asynapsis, and early meiotic arrest. Thus, Prdm9-dependent hybrid sterility points to incompatibilities affecting meiotic recombination as a possible mechanism of reproductive isolation between (sub)species.

Název v anglickém jazyce

Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility

Popis výsledku anglicky

Hybrid sterility is a critical step in the evolution of reproductive barriers between diverging taxa during the process of speciation. Recent studies of young subspecies of the house mouse revealed a multigenic nature and frequent polymorphism of hybrid sterility genes as well as the recurrent engagement of the meiosis-specific gene PR domain-containing 9 (Prdm9) and X-linked loci. Prdm9-controlled hybrid sterility is essentially chromosomal in nature, conditioned by the sequence divergence between subspecies. Depending on the Prdm9 interallelic interactions and the X-linked Hstx2 locus, the same homologs either regularly recombine and synapse, or show impaired DNA DSB repair, asynapsis, and early meiotic arrest. Thus, Prdm9-dependent hybrid sterility points to incompatibilities affecting meiotic recombination as a possible mechanism of reproductive isolation between (sub)species.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

<a href="/cs/project/GA20-04075S" target="_blank" >GA20-04075S: Úloha PRDM9 zprostředkované synapse meiotických chromozomů v hybridní sterilitě</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trends in Genetics

ISSN

0168-9525

e-ISSN

1362-4555

Svazek periodika

37

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

14

Strana od-do

1095-1108

Kód UT WoS článku

000718104000009

EID výsledku v databázi Scopus

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