gamma-Tubulin in microtubule nucleation and beyond

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00562229" target="_blank" >RIV/68378050:_____/22:00562229 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3389/fcell.2022.880761" target="_blank" >https://doi.org/10.3389/fcell.2022.880761</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcell.2022.880761" target="_blank" >10.3389/fcell.2022.880761</a>

Jazyk výsledku

angličtina

Název v původním jazyce

gamma-Tubulin in microtubule nucleation and beyond

Popis výsledku v původním jazyce

Microtubules composed of alpha betatubulin dimers are dynamic cytoskeletal polymers that play key roles in essential cellular processes such as cell division, organelle positioning, intracellular transport, and cell migration. gammaTubulin is a highly conserved member of the tubulin family that is required for microtubule nucleation. gammaTubulin, together with its associated proteins, forms the gammatubulin ring complex (gammaTuRC), that templates microtubules. Here we review recent advances in the structure of gammaTuRC, its activation, and centrosomal recruitment. This provides new mechanistic insights into the molecular mechanism of microtubule nucleation. Accumulating data suggest that gammatubulin also has other, less well understood functions. We discuss emerging evidence that gammatubulin can form oligomers and filaments, has specific nuclear functions, and might be involved in centrosomal cross-talk between microtubules and microfilaments.

Název v anglickém jazyce

gamma-Tubulin in microtubule nucleation and beyond

Popis výsledku anglicky

Microtubules composed of alpha betatubulin dimers are dynamic cytoskeletal polymers that play key roles in essential cellular processes such as cell division, organelle positioning, intracellular transport, and cell migration. gammaTubulin is a highly conserved member of the tubulin family that is required for microtubule nucleation. gammaTubulin, together with its associated proteins, forms the gammatubulin ring complex (gammaTuRC), that templates microtubules. Here we review recent advances in the structure of gammaTuRC, its activation, and centrosomal recruitment. This provides new mechanistic insights into the molecular mechanism of microtubule nucleation. Accumulating data suggest that gammatubulin also has other, less well understood functions. We discuss emerging evidence that gammatubulin can form oligomers and filaments, has specific nuclear functions, and might be involved in centrosomal cross-talk between microtubules and microfilaments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Cell and Developmental Biology

ISSN

2296-634X

e-ISSN

2296-634X

Svazek periodika

10

Číslo periodika v rámci svazku

Sep 1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

880761

Kód UT WoS článku

000859594900001

EID výsledku v databázi Scopus

2-s2.0-85138809258