UNCOVERING THE DIFFERENCES BETWEEN RESPIRATORY PATHOGEN-INDUCED T-CELLS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00580718" target="_blank" >RIV/68378050:_____/23:00580718 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/23:00580718

Výsledek na webu

<a href="http://ccsss.cz/index.php/ccsss/issue/view/41" target="_blank" >http://ccsss.cz/index.php/ccsss/issue/view/41</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

UNCOVERING THE DIFFERENCES BETWEEN RESPIRATORY PATHOGEN-INDUCED T-CELLS

Popis výsledku v původním jazyce

The upper respiratory tract (URT) is a site of entry for many public health-concerning pathogens such as SARS-CoV-2 (ref.1),the Influenza virus2, or Bordetella pertussis3. Although the URT represents an important site for initiating and transmitting infection, understanding the site-specific immunity in the nasal tissue during different infections is limited. So far, most works focused on respiratory infections have been concerned only with the lower respiratory tract (LRT)2. The adaptive immune system of URT consists of nasal-associated lymphoid tissue, which is a highly organized lymphoid structure with T and B cell areas and dispersed Tissue-resident memory T cells (Trm). Trm cells are a subset of memory T cells, which reside in non-lymphoid tissues, where they can act as alarm sensors in the immune surveillance network or as cytotoxic cells. Due to their advantageous location, they can be part of the first line of defense against many infections. The mechanism of development and the diversity and function of Trm cells are not yet completely understood4. We hypothesize that different infections such as intracellular viral infection or extracellular bacterial infection give rise to phenotypically and functionally distinct T-cell subsets. Moreover, CD4+and CD8+Trm cells induced by these infections might differ in their ability to persist in URT or LRT and respond to re-infection. To address this hypothesis we utilized two infection models: viral infection (Influenza A) and bacterial infection (Bordetella pertussis). We were able to identify various key differences between these two infections which will be further studied.

Název v anglickém jazyce

UNCOVERING THE DIFFERENCES BETWEEN RESPIRATORY PATHOGEN-INDUCED T-CELLS

Popis výsledku anglicky

The upper respiratory tract (URT) is a site of entry for many public health-concerning pathogens such as SARS-CoV-2 (ref.1),the Influenza virus2, or Bordetella pertussis3. Although the URT represents an important site for initiating and transmitting infection, understanding the site-specific immunity in the nasal tissue during different infections is limited. So far, most works focused on respiratory infections have been concerned only with the lower respiratory tract (LRT)2. The adaptive immune system of URT consists of nasal-associated lymphoid tissue, which is a highly organized lymphoid structure with T and B cell areas and dispersed Tissue-resident memory T cells (Trm). Trm cells are a subset of memory T cells, which reside in non-lymphoid tissues, where they can act as alarm sensors in the immune surveillance network or as cytotoxic cells. Due to their advantageous location, they can be part of the first line of defense against many infections. The mechanism of development and the diversity and function of Trm cells are not yet completely understood4. We hypothesize that different infections such as intracellular viral infection or extracellular bacterial infection give rise to phenotypically and functionally distinct T-cell subsets. Moreover, CD4+and CD8+Trm cells induced by these infections might differ in their ability to persist in URT or LRT and respond to re-infection. To address this hypothesis we utilized two infection models: viral infection (Influenza A) and bacterial infection (Bordetella pertussis). We were able to identify various key differences between these two infections which will be further studied.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů