Many Ways to the Cell Cycle Exit after Inhibition of CDK4/6

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00617303" target="_blank" >RIV/68378050:_____/23:00617303 - isvavai.cz</a>

Výsledek na webu

<a href="https://foliabiologica.lf1.cuni.cz/69/5/0194/" target="_blank" >https://foliabiologica.lf1.cuni.cz/69/5/0194/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/fb2023069050194" target="_blank" >10.14712/fb2023069050194</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Many Ways to the Cell Cycle Exit after Inhibition of CDK4/6

Popis výsledku v původním jazyce

Cyclin-dependent kinases (CDKs) are master regulators of proliferation, and therefore they represent attractive targets for cancer therapy. Development of selective CDK4/6 inhibitors including palbociclib revolutionized the treatment of advanced HR+/HER2– breast cancer. Inhibition of CDK4/6 leads to cell cycle arrest in G0/G1 phase and eventually to a permanent cell cycle exit called senescence. One of the main features of the senescence is an increased cell size. For many years, it was believed that the non-dividing cells simply continue to grow and as a result, they become excessively large. There is now emerging evidence that the increased cell size is a cause rather than consequence of the cell cycle arrest. This review aims to summarize recent advances in our understanding of senescence induction, in particular that resulting from treatment with CDK4/6 inhibitors.

Název v anglickém jazyce

Many Ways to the Cell Cycle Exit after Inhibition of CDK4/6

Popis výsledku anglicky

Cyclin-dependent kinases (CDKs) are master regulators of proliferation, and therefore they represent attractive targets for cancer therapy. Development of selective CDK4/6 inhibitors including palbociclib revolutionized the treatment of advanced HR+/HER2– breast cancer. Inhibition of CDK4/6 leads to cell cycle arrest in G0/G1 phase and eventually to a permanent cell cycle exit called senescence. One of the main features of the senescence is an increased cell size. For many years, it was believed that the non-dividing cells simply continue to grow and as a result, they become excessively large. There is now emerging evidence that the increased cell size is a cause rather than consequence of the cell cycle arrest. This review aims to summarize recent advances in our understanding of senescence induction, in particular that resulting from treatment with CDK4/6 inhibitors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica

ISSN

0015-5500

e-ISSN

0015-5500

Svazek periodika

69

Číslo periodika v rámci svazku

5-6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

194-196

Kód UT WoS článku

001199526300003

EID výsledku v databázi Scopus

2-s2.0-85190398748