DNA and RNA charge transport effect of sequence, stacking, structure and Hg incorporation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F13%3A00422698" target="_blank" >RIV/68378271:_____/13:00422698 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/13:00422698 RIV/00216305:26310/13:PU104677

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

DNA and RNA charge transport effect of sequence, stacking, structure and Hg incorporation

Popis výsledku v původním jazyce

In this work experimental and theoretical approaches have been combined for unique study and comparison of charge transfer efficiency in standard and modified (Hg incorporated) DNA duplexes and DNA/RNA hybrids. Specific mechanism proposed to account forthe on-chain oligonucleotide charge transport is based on polaron formation-charge is transported coherently by long-distance tunneling (superexchange). A key parameter in this approach is how the bridge orbitals of the intervening DNA bases couple the charge donor and acceptor - this is strongly controlled by specific oligomeres structures and conformation. The RNA/DNA system flexibility also improves the conditions for polaron creation and thus may facilitate rapid (coherent) charge transport in the DNA/RNA hybrids.

Název v anglickém jazyce

DNA and RNA charge transport effect of sequence, stacking, structure and Hg incorporation

Popis výsledku anglicky

In this work experimental and theoretical approaches have been combined for unique study and comparison of charge transfer efficiency in standard and modified (Hg incorporated) DNA duplexes and DNA/RNA hybrids. Specific mechanism proposed to account forthe on-chain oligonucleotide charge transport is based on polaron formation-charge is transported coherently by long-distance tunneling (superexchange). A key parameter in this approach is how the bridge orbitals of the intervening DNA bases couple the charge donor and acceptor - this is strongly controlled by specific oligomeres structures and conformation. The RNA/DNA system flexibility also improves the conditions for polaron creation and thus may facilitate rapid (coherent) charge transport in the DNA/RNA hybrids.

Druh

O - Ostatní výsledky

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů