Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F14%3A00436869" target="_blank" >RIV/68378271:_____/14:00436869 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/14:00436869 RIV/61389013:_____/14:00436869

Výsledek na webu

<a href="http://dx.doi.org/10.1038/srep07129" target="_blank" >http://dx.doi.org/10.1038/srep07129</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/srep07129" target="_blank" >10.1038/srep07129</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations

Popis výsledku v původním jazyce

Non-thermal plasma has been recognized as a promising tool across a vast variety of biomedical applications, with the potential of creating novel therapeutic methods. However, the understanding of the molecular mechanisms behind non-thermal plasma cellular effects remains a significant challenge. In this study, we show how two types of different non-thermal plasmas induce cell death in mammalian cell cultures via the formation of multiple intracellular reactive oxygen/nitrogen species. Our results showed a discrepancy in the superoxide accumulation and lysosomal activity in response to air and helium plasma,suggesting that triggered signalling cascades might be grossly different between different plasmas. Inaddition, the effects of ozone, a considerable component of non-thermal plasma, have been simultaneously evaluated and have revealed much faster and higher cytotoxic effects.

Název v anglickém jazyce

Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations

Popis výsledku anglicky

Non-thermal plasma has been recognized as a promising tool across a vast variety of biomedical applications, with the potential of creating novel therapeutic methods. However, the understanding of the molecular mechanisms behind non-thermal plasma cellular effects remains a significant challenge. In this study, we show how two types of different non-thermal plasmas induce cell death in mammalian cell cultures via the formation of multiple intracellular reactive oxygen/nitrogen species. Our results showed a discrepancy in the superoxide accumulation and lysosomal activity in response to air and helium plasma,suggesting that triggered signalling cascades might be grossly different between different plasmas. Inaddition, the effects of ozone, a considerable component of non-thermal plasma, have been simultaneously evaluated and have revealed much faster and higher cytotoxic effects.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/LO1309" target="_blank" >LO1309: Buněčná terapie a tkáňové náhrady</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

NOV

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000346178100001

EID výsledku v databázi Scopus

—