Static high-gradient magnetic fields affect the functionality of monocytic cells

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Static high-gradient magnetic fields affect the functionality of monocytic cells

Popis výsledku v původním jazyce

Magnetic fields, different to electric fields, can intrude into deeper layers of tissue, where they could modulate biochemical processes. In this context, we explored the cellular effects of specifically designed high-performance micro-magnet arrays which, in contrast to conventional magnets, generate high-gradient magnetic fields not encountered in the environment. Exposure of monocytic cells to high-gradient magnetic fields of various strength generated by micro-magnet arrays induced cell swelling followed by accumulation of reactive oxygen species (ROS), and inhibition of cell proliferation. High levels of ROS may damage cellular structures and induce apoptosis. Consistently, prolonged exposure of cells to high-gradient magnetic fields induced time-dependent translocation of phosphatidylserine to the outer leaflet of the membrane.

Název v anglickém jazyce

Static high-gradient magnetic fields affect the functionality of monocytic cells

Popis výsledku anglicky

Magnetic fields, different to electric fields, can intrude into deeper layers of tissue, where they could modulate biochemical processes. In this context, we explored the cellular effects of specifically designed high-performance micro-magnet arrays which, in contrast to conventional magnets, generate high-gradient magnetic fields not encountered in the environment. Exposure of monocytic cells to high-gradient magnetic fields of various strength generated by micro-magnet arrays induced cell swelling followed by accumulation of reactive oxygen species (ROS), and inhibition of cell proliferation. High levels of ROS may damage cellular structures and induce apoptosis. Consistently, prolonged exposure of cells to high-gradient magnetic fields induced time-dependent translocation of phosphatidylserine to the outer leaflet of the membrane.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů