Determination of optical purity of lactic acid-based chiral liquid crystals and corresponding building blocks by chiral high-performance liquid chromatography and supercritical fluid chromatography

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F19%3A00511153" target="_blank" >RIV/68378271:_____/19:00511153 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/19:43919055 RIV/60461373:22330/19:43919055 RIV/60461373:22810/19:43919055

Výsledek na webu

<a href="http://hdl.handle.net/11104/0301482" target="_blank" >http://hdl.handle.net/11104/0301482</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules24061099" target="_blank" >10.3390/molecules24061099</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Determination of optical purity of lactic acid-based chiral liquid crystals and corresponding building blocks by chiral high-performance liquid chromatography and supercritical fluid chromatography

Popis výsledku v původním jazyce

In this study we aimed to verify synthetic methods of liquid crystals (LCs) recently published in the literature, which are used nowadays to prepare chiral building blocks based on lactic acid, for their enantioselectivity. We have focused on the development of an analytical chiral separation method for target liquid crystalline materials. Using a chiral polysaccharide-based column operated in liquid chromatography mode, we show that not all published methods of LC synthesis are enantioselective, which could lead to significant differences in the properties of the resulting materials. We show that high-performance liquid chromatography with UV detection and supercritical fluid chromatography with UV and mass spectrometry detection enable full control over the chemical and optical purity of the target LCs and the corresponding chiral building blocks.

Název v anglickém jazyce

Determination of optical purity of lactic acid-based chiral liquid crystals and corresponding building blocks by chiral high-performance liquid chromatography and supercritical fluid chromatography

Popis výsledku anglicky

In this study we aimed to verify synthetic methods of liquid crystals (LCs) recently published in the literature, which are used nowadays to prepare chiral building blocks based on lactic acid, for their enantioselectivity. We have focused on the development of an analytical chiral separation method for target liquid crystalline materials. Using a chiral polysaccharide-based column operated in liquid chromatography mode, we show that not all published methods of LC synthesis are enantioselective, which could lead to significant differences in the properties of the resulting materials. We show that high-performance liquid chromatography with UV detection and supercritical fluid chromatography with UV and mass spectrometry detection enable full control over the chemical and optical purity of the target LCs and the corresponding chiral building blocks.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/GJ16-17689Y" target="_blank" >GJ16-17689Y: Nové chirální stacionární fáze ionexové povahy pro enantiomerní separace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecules

ISSN

1420-3049

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

000465503800075

EID výsledku v databázi Scopus

2-s2.0-85063573780