A vesicle-to-sponge transition via the proliferation of membrane-linking pores in omega-3 polyunsaturated fatty acid-containing lipid assemblies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F19%3A00520788" target="_blank" >RIV/68378271:_____/19:00520788 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.molliq.2019.01.124" target="_blank" >https://doi.org/10.1016/j.molliq.2019.01.124</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molliq.2019.01.124" target="_blank" >10.1016/j.molliq.2019.01.124</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A vesicle-to-sponge transition via the proliferation of membrane-linking pores in omega-3 polyunsaturated fatty acid-containing lipid assemblies

Popis výsledku v původním jazyce

Nanostructure evolution and the membrane reorganization of diluted lipid dispersions of selfassembled monoolein (MO)/eicosapentaenoic acid (EPA, 20:5) mixtures by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) microscopy.At ambient temperature, the topological transition occurred through the proliferation ofmembrane-linking pores (MLP)within the individual lipid nanoparticles. The density of the MLP pores varied starting from the nanoparticle center toward the periphery. The generation of MLP is governed by the amphiphilic composition and leads to formation of 3D networks of aqueous channels inside the nanoparticles, i.e. spongosomes. It can be concluded that the incorporation of a ω-3 polyunsaturated fatty acid at increasing concentration causes swelling inhibition (dehydration) of the host liquid crystalline architectures.

Název v anglickém jazyce

A vesicle-to-sponge transition via the proliferation of membrane-linking pores in omega-3 polyunsaturated fatty acid-containing lipid assemblies

Popis výsledku anglicky

Nanostructure evolution and the membrane reorganization of diluted lipid dispersions of selfassembled monoolein (MO)/eicosapentaenoic acid (EPA, 20:5) mixtures by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) microscopy.At ambient temperature, the topological transition occurred through the proliferation ofmembrane-linking pores (MLP)within the individual lipid nanoparticles. The density of the MLP pores varied starting from the nanoparticle center toward the periphery. The generation of MLP is governed by the amphiphilic composition and leads to formation of 3D networks of aqueous channels inside the nanoparticles, i.e. spongosomes. It can be concluded that the incorporation of a ω-3 polyunsaturated fatty acid at increasing concentration causes swelling inhibition (dehydration) of the host liquid crystalline architectures.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

<a href="/cs/project/LQ1606" target="_blank" >LQ1606: ELI Beamlines: Mezinárodní centrum Excelemce</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular Liquids

ISSN

0167-7322

e-ISSN

—

Svazek periodika

279

Číslo periodika v rámci svazku

Apr

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

518-523

Kód UT WoS článku

000462101800053

EID výsledku v databázi Scopus

2-s2.0-85061186850