Low-dimensional compounds containing bioactive ligands. Part XIII: Square planar anti-cancer Pd(II) complexes with halogenderivatives of 8-quinolinol and dimethylamine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00537729" target="_blank" >RIV/68378271:_____/20:00537729 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.poly.2020.114535" target="_blank" >https://doi.org/10.1016/j.poly.2020.114535</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.poly.2020.114535" target="_blank" >10.1016/j.poly.2020.114535</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low-dimensional compounds containing bioactive ligands. Part XIII: Square planar anti-cancer Pd(II) complexes with halogenderivatives of 8-quinolinol and dimethylamine

Popis výsledku v původním jazyce

Four new Pd(II) complexes with halogenderivatives of 8-quinolinol (HXQ) were prepared: [PdCl(NH(CH3)2)(CQ)] (1), [PdCl(NH(CH3)2)(dClQ)] (2), [PdCl(NH(CH3)2)(dBrQ)] (3) and [PdCl(NH(CH3)2)(BrQ)](4) The infrared spectroscopy confirmed the presence of XQ moiety in all complexes as well as dimethylamine ligands resulting from the decomposition of DMF used as solvent. Subsequent X-ray analysis revealed the structure of the complexes. All the prepared complexes were toxic to the tumor cells and the higher cytotoxicity was induced by complex 1 against A549 cells at very low concentrations which would provide new potential antitumor drug that deserves much more attention in lung cancer research.n

Název v anglickém jazyce

Low-dimensional compounds containing bioactive ligands. Part XIII: Square planar anti-cancer Pd(II) complexes with halogenderivatives of 8-quinolinol and dimethylamine

Popis výsledku anglicky

Four new Pd(II) complexes with halogenderivatives of 8-quinolinol (HXQ) were prepared: [PdCl(NH(CH3)2)(CQ)] (1), [PdCl(NH(CH3)2)(dClQ)] (2), [PdCl(NH(CH3)2)(dBrQ)] (3) and [PdCl(NH(CH3)2)(BrQ)](4) The infrared spectroscopy confirmed the presence of XQ moiety in all complexes as well as dimethylamine ligands resulting from the decomposition of DMF used as solvent. Subsequent X-ray analysis revealed the structure of the complexes. All the prepared complexes were toxic to the tumor cells and the higher cytotoxicity was induced by complex 1 against A549 cells at very low concentrations which would provide new potential antitumor drug that deserves much more attention in lung cancer research.n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

<a href="/cs/project/LO1603" target="_blank" >LO1603: Centrum technologie a pokročilé strukturní analýzy aplikačně významných materiálů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polyhedron

ISSN

0277-5387

e-ISSN

—

Svazek periodika

184

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

000540348300003

EID výsledku v databázi Scopus

2-s2.0-85083481751