Immuno-probed graphene nanoplatelets on electrolyte-gated field-effect transistor for stable cortisol quantification in serum

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00540097" target="_blank" >RIV/68378271:_____/20:00540097 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/20:00346858

Výsledek na webu

<a href="https://doi.org/10.1016/j.jtice.2020.12.008" target="_blank" >https://doi.org/10.1016/j.jtice.2020.12.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jtice.2020.12.008" target="_blank" >10.1016/j.jtice.2020.12.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Immuno-probed graphene nanoplatelets on electrolyte-gated field-effect transistor for stable cortisol quantification in serum

Popis výsledku v původním jazyce

This study reports immuno-probed graphene nanoplatelets on electrolyte-gated field-effect transistor (EGFET) biosensor for cortisol determination in human serum. Solution-processed graphene nanoplatelets were evidenced by Raman spectroscopy and utilized as the transducing element on the FET. Further, confirmed the binding events of the antibody on graphene nanoplatelets using XPS and characterized the electrostatic gating effect of cortisol and intermediate functionalization on graphene nanoplatelets-EGFET. The biosensor exhibited good sensitivity of 72.30 uA.(g/mL)-1 in a linear range between 1.00 pg/mL to 10.00 ng/mL, with a limit of detection (LOD) of 0.85 pg/mL. Cortisol was also successfully detected with interference by the human serum, suggesting the capability of graphene nanoplatelets-EGFET sensor for determining cortisol in a complex matrix.

Název v anglickém jazyce

Immuno-probed graphene nanoplatelets on electrolyte-gated field-effect transistor for stable cortisol quantification in serum

Popis výsledku anglicky

This study reports immuno-probed graphene nanoplatelets on electrolyte-gated field-effect transistor (EGFET) biosensor for cortisol determination in human serum. Solution-processed graphene nanoplatelets were evidenced by Raman spectroscopy and utilized as the transducing element on the FET. Further, confirmed the binding events of the antibody on graphene nanoplatelets using XPS and characterized the electrostatic gating effect of cortisol and intermediate functionalization on graphene nanoplatelets-EGFET. The biosensor exhibited good sensitivity of 72.30 uA.(g/mL)-1 in a linear range between 1.00 pg/mL to 10.00 ng/mL, with a limit of detection (LOD) of 0.85 pg/mL. Cortisol was also successfully detected with interference by the human serum, suggesting the capability of graphene nanoplatelets-EGFET sensor for determining cortisol in a complex matrix.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21101 - Food and beverages

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Taiwan Institute of Chemical Engineers

ISSN

1876-1070

e-ISSN

—

Svazek periodika

117

Číslo periodika v rámci svazku

Dec

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

10-18

Kód UT WoS článku

000614633300002

EID výsledku v databázi Scopus

2-s2.0-85098126685