Radiobiological outcomes, microdosimetric evaluations and Monte Carlo predictions in eye proton therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00565893" target="_blank" >RIV/68378271:_____/21:00565893 - isvavai.cz</a>

Výsledek na webu

<a href="https://hdl.handle.net/11104/0337371" target="_blank" >https://hdl.handle.net/11104/0337371</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/app11198822" target="_blank" >10.3390/app11198822</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiobiological outcomes, microdosimetric evaluations and Monte Carlo predictions in eye proton therapy

Popis výsledku v původním jazyce

CATANA was the first Italian protontherapy facility dedicated to the treatment of ocular neoplastic pathologies. It is in operation at the LNS Laboratories of the Italian Institute for Nuclear Physics and to date, 500 patients have been successfully treated. Even though proton therapy has demonstrated success in clinical settings, there is still a need for more accurate models because they are crucial for the estimation of clinically relevant RBE values. Since RBE can vary depending on several physical and biological parameters, there is a clear need for more experimental data to generate predictions. Establishing a database of cell survival experiments is therefore useful to accurately predict the effects of irradiations on both cancerous and normal tissue. The main aim of this work was to compare RBE values obtained from in-vitro experimental data with predictions made by the LEM II, Monte Carlo approaches, and semi-empirical models based on LET experimental measurements.n

Název v anglickém jazyce

Radiobiological outcomes, microdosimetric evaluations and Monte Carlo predictions in eye proton therapy

Popis výsledku anglicky

CATANA was the first Italian protontherapy facility dedicated to the treatment of ocular neoplastic pathologies. It is in operation at the LNS Laboratories of the Italian Institute for Nuclear Physics and to date, 500 patients have been successfully treated. Even though proton therapy has demonstrated success in clinical settings, there is still a need for more accurate models because they are crucial for the estimation of clinically relevant RBE values. Since RBE can vary depending on several physical and biological parameters, there is a clear need for more experimental data to generate predictions. Establishing a database of cell survival experiments is therefore useful to accurately predict the effects of irradiations on both cancerous and normal tissue. The main aim of this work was to compare RBE values obtained from in-vitro experimental data with predictions made by the LEM II, Monte Carlo approaches, and semi-empirical models based on LET experimental measurements.n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10303 - Particles and field physics

Projekt

<a href="/cs/project/EF20_079%2F0017754" target="_blank" >EF20_079/0017754: Mezinárodní mobilita MSCA-IF IV FZU</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Sciences-Basel

ISSN

2076-3417

e-ISSN

2076-3417

Svazek periodika

11

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

8822

Kód UT WoS článku

000707965800001

EID výsledku v databázi Scopus

2-s2.0-85115735332