Synthesis, characterization, cytotoxicity and DNA/BSA binding of two amino acid palladium(II) complexes derived from alanine and valine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00556291" target="_blank" >RIV/68378271:_____/22:00556291 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1080/15257770.2021.2011914" target="_blank" >https://doi.org/10.1080/15257770.2021.2011914</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15257770.2021.2011914" target="_blank" >10.1080/15257770.2021.2011914</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, characterization, cytotoxicity and DNA/BSA binding of two amino acid palladium(II) complexes derived from alanine and valine

Popis výsledku v původním jazyce

Two novel palladium(II)–amino acid complexes, [Pd(Ala)2]·H2O (PA) and [Pd(Val)2].H2O (PV) (Ala = alanine, Val = valine) were synthesized and characterized through FTIR, UV/Vis, 1H-NMR spectroscopies, CHN analysis, X-ray crystallography and molar conductivity measurement. Furthermore, cytotoxicity of Pd(II) complexes against human leukemia cancer cell line, MOLT4 showed promising cancer cell death that were less than cisplatin. Moreover, the interaction of both the complexes with DNA and BSA was studied using UV–Vis absorption and emission spectroscopic techniques that demonstrated the bindin gs occurred via van der Waals forces and hydrogen bond.

Název v anglickém jazyce

Synthesis, characterization, cytotoxicity and DNA/BSA binding of two amino acid palladium(II) complexes derived from alanine and valine

Popis výsledku anglicky

Two novel palladium(II)–amino acid complexes, [Pd(Ala)2]·H2O (PA) and [Pd(Val)2].H2O (PV) (Ala = alanine, Val = valine) were synthesized and characterized through FTIR, UV/Vis, 1H-NMR spectroscopies, CHN analysis, X-ray crystallography and molar conductivity measurement. Furthermore, cytotoxicity of Pd(II) complexes against human leukemia cancer cell line, MOLT4 showed promising cancer cell death that were less than cisplatin. Moreover, the interaction of both the complexes with DNA and BSA was studied using UV–Vis absorption and emission spectroscopic techniques that demonstrated the bindin gs occurred via van der Waals forces and hydrogen bond.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nucleosides Nucleotides & Nucleic Acids

ISSN

1525-7770

e-ISSN

1532-2335

Svazek periodika

41

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

26

Strana od-do

97-122

Kód UT WoS článku

000728413600001

EID výsledku v databázi Scopus

2-s2.0-85121399979