Characterization and insights into the formation of new multicomponent solid forms of sofosbuvir

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00558650" target="_blank" >RIV/68378271:_____/22:00558650 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/22:43925021 RIV/60461373:22340/22:43925021

Výsledek na webu

<a href="https://doi.org/10.1021/acs.cgd.2c00207" target="_blank" >https://doi.org/10.1021/acs.cgd.2c00207</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.cgd.2c00207" target="_blank" >10.1021/acs.cgd.2c00207</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterization and insights into the formation of new multicomponent solid forms of sofosbuvir

Popis výsledku v původním jazyce

Sofosbuvir, a drug used for the treatment of hepatitis C, is known to have several polymorphs. However, its ability to form multicomponent solid forms has been little researched, and only the crystal structure of one cocrystal has been reported until today. In this work, with the methods of slurry experiments, solution evaporation, and mechanochemistry, we synthesized three cocrystals, two solvates, and two coamorphous systems of sofosbuvir, for which we provide full characterization. Furthermore, we solved the crystal structures of the multicomponent solid forms of sofosbuvir with piperazine, di chloromethane, and chloroform, allowing us to investigate, compare, and discuss their molecular interaction energies.

Název v anglickém jazyce

Characterization and insights into the formation of new multicomponent solid forms of sofosbuvir

Popis výsledku anglicky

Sofosbuvir, a drug used for the treatment of hepatitis C, is known to have several polymorphs. However, its ability to form multicomponent solid forms has been little researched, and only the crystal structure of one cocrystal has been reported until today. In this work, with the methods of slurry experiments, solution evaporation, and mechanochemistry, we synthesized three cocrystals, two solvates, and two coamorphous systems of sofosbuvir, for which we provide full characterization. Furthermore, we solved the crystal structures of the multicomponent solid forms of sofosbuvir with piperazine, di chloromethane, and chloroform, allowing us to investigate, compare, and discuss their molecular interaction energies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Crystal Growth & Design

ISSN

1528-7483

e-ISSN

1528-7505

Svazek periodika

22

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

3395-3404

Kód UT WoS článku

000812744700001

EID výsledku v databázi Scopus

2-s2.0-85127850053