Explaining dissolution properties of rivaroxaban cocrystals
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00558894" target="_blank" >RIV/68378271:_____/22:00558894 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60461373:22310/22:43925026 RIV/60461373:22340/22:43925026 RIV/00064165:_____/22:10448717 RIV/00216208:11110/22:10448717 RIV/00216208:11310/22:10448717
Výsledek na webu
<a href="https://doi.org/10.1016/j.ijpharm.2022.121854" target="_blank" >https://doi.org/10.1016/j.ijpharm.2022.121854</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2022.121854" target="_blank" >10.1016/j.ijpharm.2022.121854</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Explaining dissolution properties of rivaroxaban cocrystals
Popis výsledku v původním jazyce
The aim of this study was to improve rivaroxaban water-solubility by cocrystal preparation and to understand this process. The screening with water-soluble coformers was performed via both mechanochemical and solutionmediated techniques. Two cocrystals of rivaroxaban with malonic acid and oxalic acid were prepared, and the structure of the cocrystal with oxalic acid was solved. Both cocrystals exhibit improved dissolution properties. The mechanism of the supersaturation maintenance was studied by in-situ Raman spectroscopy. The transformation into rivaroxaban dihydrate was identified as the criti cal step in the improved dissolution properties of both cocrystals. Moreover, the transformation kinetics and solubilization effects of the coformers were identified as responsible for the differences in the dissolution behavior of the cocrystals.
Název v anglickém jazyce
Explaining dissolution properties of rivaroxaban cocrystals
Popis výsledku anglicky
The aim of this study was to improve rivaroxaban water-solubility by cocrystal preparation and to understand this process. The screening with water-soluble coformers was performed via both mechanochemical and solutionmediated techniques. Two cocrystals of rivaroxaban with malonic acid and oxalic acid were prepared, and the structure of the cocrystal with oxalic acid was solved. Both cocrystals exhibit improved dissolution properties. The mechanism of the supersaturation maintenance was studied by in-situ Raman spectroscopy. The transformation into rivaroxaban dihydrate was identified as the criti cal step in the improved dissolution properties of both cocrystals. Moreover, the transformation kinetics and solubilization effects of the coformers were identified as responsible for the differences in the dissolution behavior of the cocrystals.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
1873-3476
Svazek periodika
622
Číslo periodika v rámci svazku
June
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
10
Strana od-do
121854
Kód UT WoS článku
000812200200005
EID výsledku v databázi Scopus
2-s2.0-85131129441