Intermittent F-actin perturbations by magnetic fields inhibit breast cancer metastasis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00570700" target="_blank" >RIV/68378271:_____/23:00570700 - isvavai.cz</a>

Výsledek na webu

<a href="https://hdl.handle.net/11104/0342024" target="_blank" >https://hdl.handle.net/11104/0342024</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.34133/research.0080" target="_blank" >10.34133/research.0080</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Intermittent F-actin perturbations by magnetic fields inhibit breast cancer metastasis

Popis výsledku v původním jazyce

F-actin (filamentous actin) has been shown to be sensitive to mechanical stimuli and play critical roles in cell attachment, migration, and cancer metastasis, but there are very limited ways to perturb F-actin dynamics with low cell toxicity. Magnetic field is a noninvasive and reversible physical tool that can easily penetrate cells and human bodies. Here, we show that 0.1/0.4-T 4.2-Hz moderate-intensity low-frequency rotating magnetic field-induced electric field could directly decrease F-actin formation in vitro and in vivo, which results in decreased breast cancer cell migration, invasion, and attachment. Moreover, low- frequency rotating magnetic fields generated significantly different effects on F-actin in breast cancer vs. noncancerous cells, including F-actin number and their recovery after magnetic field retrieval.

Název v anglickém jazyce

Intermittent F-actin perturbations by magnetic fields inhibit breast cancer metastasis

Popis výsledku anglicky

F-actin (filamentous actin) has been shown to be sensitive to mechanical stimuli and play critical roles in cell attachment, migration, and cancer metastasis, but there are very limited ways to perturb F-actin dynamics with low cell toxicity. Magnetic field is a noninvasive and reversible physical tool that can easily penetrate cells and human bodies. Here, we show that 0.1/0.4-T 4.2-Hz moderate-intensity low-frequency rotating magnetic field-induced electric field could directly decrease F-actin formation in vitro and in vivo, which results in decreased breast cancer cell migration, invasion, and attachment. Moreover, low- frequency rotating magnetic fields generated significantly different effects on F-actin in breast cancer vs. noncancerous cells, including F-actin number and their recovery after magnetic field retrieval.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

<a href="/cs/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Fyzika pevných látek pro 21. století</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Research

ISSN

2096-5168

e-ISSN

2639-5274

Svazek periodika

6

Číslo periodika v rámci svazku

Mar

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

0080

Kód UT WoS článku

000931340200001

EID výsledku v databázi Scopus

2-s2.0-85152141551