Effects of gradient high-field static magnetic fields on diabetic mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00570706" target="_blank" >RIV/68378271:_____/23:00570706 - isvavai.cz</a>

Výsledek na webu

<a href="https://hdl.handle.net/11104/0342031" target="_blank" >https://hdl.handle.net/11104/0342031</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.24272/j.issn.2095-8137.2022.460" target="_blank" >10.24272/j.issn.2095-8137.2022.460</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of gradient high-field static magnetic fields on diabetic mice

Popis výsledku v původním jazyce

Although 9.4 T magnetic resonance imaging (MRI) has been tested in healthy volunteers, its safety in diabetic patients is unclear. Furthermore, the effects of high static magnetic fields (SMFs), especially gradient vs. uniform fields, have not been investigated in diabetics. Here, we investigated the consequences of exposure to 1.0–9.4 T high SMFs of different gradients (>10 T/m vs. 0–10 T/m) on type 1 diabetic (T1D) and type 2 diabetic (T2D) mice. We found that 14 h of prolonged treatment of gradient (as high as 55.5 T/m) high SMFs (1.0–8.6 T) had negative effects on T1D and T2D mice, including spleen, hepatic, and renal tissue impairment and elevated glycosylated serum protein, blood glucose, inflammation, and anxiety, while 9.4 T quasi-uniform SMFs at 0–10 T/m did not induce the same effects. In regular T1D mice (blood glucose ≥16.7 mM), the >10 T/m gradient high SMFs increased malondialdehyde (P<0.01) and decreased superoxide dismutase (P<0.05).

Název v anglickém jazyce

Effects of gradient high-field static magnetic fields on diabetic mice

Popis výsledku anglicky

Although 9.4 T magnetic resonance imaging (MRI) has been tested in healthy volunteers, its safety in diabetic patients is unclear. Furthermore, the effects of high static magnetic fields (SMFs), especially gradient vs. uniform fields, have not been investigated in diabetics. Here, we investigated the consequences of exposure to 1.0–9.4 T high SMFs of different gradients (>10 T/m vs. 0–10 T/m) on type 1 diabetic (T1D) and type 2 diabetic (T2D) mice. We found that 14 h of prolonged treatment of gradient (as high as 55.5 T/m) high SMFs (1.0–8.6 T) had negative effects on T1D and T2D mice, including spleen, hepatic, and renal tissue impairment and elevated glycosylated serum protein, blood glucose, inflammation, and anxiety, while 9.4 T quasi-uniform SMFs at 0–10 T/m did not induce the same effects. In regular T1D mice (blood glucose ≥16.7 mM), the >10 T/m gradient high SMFs increased malondialdehyde (P<0.01) and decreased superoxide dismutase (P<0.05).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ZOOLOGICAL RESEARCH

ISSN

2095-8137

e-ISSN

—

Svazek periodika

44

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

10

Strana od-do

249-258

Kód UT WoS článku

000972105700001

EID výsledku v databázi Scopus

2-s2.0-85146411166