In vitro cytotoxicity evaluation of organotin(IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00577711" target="_blank" >RIV/68378271:_____/23:00577711 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.molliq.2023.123442" target="_blank" >https://doi.org/10.1016/j.molliq.2023.123442</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molliq.2023.123442" target="_blank" >10.1016/j.molliq.2023.123442</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro cytotoxicity evaluation of organotin(IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies

Popis výsledku v původním jazyce

Considering the valuable position of organotins and the biotic role of phosphorus compounds in biological processes, in this research work, we investigated and introduced a new class of anticancer candidates based on organotin(IV) complexes derived from bisphosphoramide ligands. Four selected complexes were prepared from the reaction of SnMe2Cl2 (C1), SnBu3Cl (C2), SnPh2Cl2 (C3), and SnPh3Cl (C4) metal salts with piperazine-1,4-diylbis(diphenylphosphine oxide) ligand (LP). The newly synthesized complexes were characterized using spectroscopic techniques. Single crystal of C1 structure was determined by X-ray crystallography. Binding potentials of compounds to DNA were also explored using electron absorption titration and competitive fluorescence quenching techniques, which indicated that complexes and CT-DNA strongly interacted.

Název v anglickém jazyce

In vitro cytotoxicity evaluation of organotin(IV) complexes derived from bisphosphoramide ligand: DNA binding and molecular docking studies

Popis výsledku anglicky

Considering the valuable position of organotins and the biotic role of phosphorus compounds in biological processes, in this research work, we investigated and introduced a new class of anticancer candidates based on organotin(IV) complexes derived from bisphosphoramide ligands. Four selected complexes were prepared from the reaction of SnMe2Cl2 (C1), SnBu3Cl (C2), SnPh2Cl2 (C3), and SnPh3Cl (C4) metal salts with piperazine-1,4-diylbis(diphenylphosphine oxide) ligand (LP). The newly synthesized complexes were characterized using spectroscopic techniques. Single crystal of C1 structure was determined by X-ray crystallography. Binding potentials of compounds to DNA were also explored using electron absorption titration and competitive fluorescence quenching techniques, which indicated that complexes and CT-DNA strongly interacted.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

<a href="/cs/project/LM2018110" target="_blank" >LM2018110: Výzkumná infrastruktura CzechNanoLab</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular Liquids

ISSN

0167-7322

e-ISSN

1873-3166

Svazek periodika

13

Číslo periodika v rámci svazku

Dec

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

16

Strana od-do

123442

Kód UT WoS článku

001105654500001

EID výsledku v databázi Scopus

2-s2.0-85175309373