Nanocomposite hydrogels from nanodiamonds and a self-assembling tripeptide

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F24%3A00603139" target="_blank" >RIV/68378271:_____/24:00603139 - isvavai.cz</a>

Výsledek na webu

<a href="https://hdl.handle.net/11104/0361429" target="_blank" >https://hdl.handle.net/11104/0361429</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chem.202402961" target="_blank" >10.1002/chem.202402961</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanocomposite hydrogels from nanodiamonds and a self-assembling tripeptide

Popis výsledku v původním jazyce

We report the successful assembly of a tripeptide in the presence of nanodiamonds (NDs) into nanocomposite hydrogels. While the presence of NDs does not hinder peptide selfassembly and gelation kinetics are not affected, NDs improve the viscoelastic properties and significantly increase the elastic moduli of the peptide hydrogels. Increased resistance of the gels against applied stress can also be attained depending on the amount of NDs loaded in the nanocomposite. Raman micro-spectroscopy and TEM confirmed the presence of NDs on the surface, and not in the interior, of peptide nanofibers. Peptide-ND non-covalent interactions are also probed by Raman and Fourier-transformed infrared spectroscopies. Overall, this work enables the embedding of NDs into nanocomposite hydrogels formed through the self-assembly of a simple tripeptide at physiological pH, and it provides key insights to open the way for their future applications in biomaterials, for instance exploiting their luminescence and near-infrared responsiveness.

Název v anglickém jazyce

Nanocomposite hydrogels from nanodiamonds and a self-assembling tripeptide

Popis výsledku anglicky

We report the successful assembly of a tripeptide in the presence of nanodiamonds (NDs) into nanocomposite hydrogels. While the presence of NDs does not hinder peptide selfassembly and gelation kinetics are not affected, NDs improve the viscoelastic properties and significantly increase the elastic moduli of the peptide hydrogels. Increased resistance of the gels against applied stress can also be attained depending on the amount of NDs loaded in the nanocomposite. Raman micro-spectroscopy and TEM confirmed the presence of NDs on the surface, and not in the interior, of peptide nanofibers. Peptide-ND non-covalent interactions are also probed by Raman and Fourier-transformed infrared spectroscopies. Overall, this work enables the embedding of NDs into nanocomposite hydrogels formed through the self-assembly of a simple tripeptide at physiological pH, and it provides key insights to open the way for their future applications in biomaterials, for instance exploiting their luminescence and near-infrared responsiveness.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GA23-04876S" target="_blank" >GA23-04876S: Nanodiamanty jako selektivní proteinové pasti k regulaci poruch způsobených aberantní signalizací FGF2</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemistry - A European Journal

ISSN

0947-6539

e-ISSN

1521-3765

Svazek periodika

30

Číslo periodika v rámci svazku

70

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

e202402961

Kód UT WoS článku

001357342800001

EID výsledku v databázi Scopus

2-s2.0-85208252231