Surface analysis of cannabigerol cocrystals: linking crystal structure to enhanced properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00618797" target="_blank" >RIV/68378271:_____/25:00618797 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/25:43933250 RIV/60461373:22340/25:43933250

Výsledek na webu

<a href="https://hdl.handle.net/11104/0366525" target="_blank" >https://hdl.handle.net/11104/0366525</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1107/S2052252525001009" target="_blank" >10.1107/S2052252525001009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Surface analysis of cannabigerol cocrystals: linking crystal structure to enhanced properties

Popis výsledku v původním jazyce

Cannabigerol is a bioactive compound derived from Cannabis sativa. Its use and research are complicated by its thermally unstable solid form with low solubility and needle habit, preventing easy formulation into tablets or capsules. To overcome these problems, we conducted a crystallization screening with the aim to discover new crystal forms with enhanced properties. Though polymorph and solvate screenings did not yield new forms, the cocrystal screening was successful. Two cocrystals were discovered, one with piperazine and another with tetramethylpirazine, both in a 1:1 ratio. The new solid forms were analysed by a combination of methods, including X-ray powder diffraction, nuclear magnetic resonance spectroscopy, differential scanning calorimetry, thermogravimetric analysis and intrinsic dissolution rate. Single-crystal X-ray diffraction data were used to solve the crystal structures, which were then compared with that of pure CBG.

Název v anglickém jazyce

Surface analysis of cannabigerol cocrystals: linking crystal structure to enhanced properties

Popis výsledku anglicky

Cannabigerol is a bioactive compound derived from Cannabis sativa. Its use and research are complicated by its thermally unstable solid form with low solubility and needle habit, preventing easy formulation into tablets or capsules. To overcome these problems, we conducted a crystallization screening with the aim to discover new crystal forms with enhanced properties. Though polymorph and solvate screenings did not yield new forms, the cocrystal screening was successful. Two cocrystals were discovered, one with piperazine and another with tetramethylpirazine, both in a 1:1 ratio. The new solid forms were analysed by a combination of methods, including X-ray powder diffraction, nuclear magnetic resonance spectroscopy, differential scanning calorimetry, thermogravimetric analysis and intrinsic dissolution rate. Single-crystal X-ray diffraction data were used to solve the crystal structures, which were then compared with that of pure CBG.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IUCrJ

ISSN

2052-2525

e-ISSN

2052-2525

Svazek periodika

12

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

141-154

Kód UT WoS článku

001437426800003

EID výsledku v databázi Scopus

2-s2.0-86000489326