Surface chemical and electronic properties of functionalized Fe3O4 nanoparticles influencing their cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00619411" target="_blank" >RIV/68378271:_____/25:00619411 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.apsusc.2024.161873" target="_blank" >https://doi.org/10.1016/j.apsusc.2024.161873</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsusc.2024.161873" target="_blank" >10.1016/j.apsusc.2024.161873</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Surface chemical and electronic properties of functionalized Fe3O4 nanoparticles influencing their cytotoxicity

Popis výsledku v původním jazyce

Physico-chemical, electronic and magnetic properties of bare Fe3O4 nanoparticles (NPs) and functionalized NPs (f-NPs) with doxorubicin, tannic acid, curcumin, polyethylene glycol and their mixtures were determined using DLS, XRD, XPS and AES. The cytotoxicity of bare and f-NPs for various cell lines such as normal HEK-293 and cancer HeLa, MDA-MB-231, and MCF-7 was studied by MTT assay. Bare and f-NPs exhibited different cytotoxicity dependent on molecules bonding at the surface. Cytotoxicity increases with decreasing hydrodynamic diameter and increasing Zeta-potential, increasing content of lattice and adsorbed O2-, carboxyl groups and C vacancies, NH4+ groups, decreasing overlayer thickness, electron charge transfer to oxygen and more nucleophilic character of electron rich surface oxygen.

Název v anglickém jazyce

Surface chemical and electronic properties of functionalized Fe3O4 nanoparticles influencing their cytotoxicity

Popis výsledku anglicky

Physico-chemical, electronic and magnetic properties of bare Fe3O4 nanoparticles (NPs) and functionalized NPs (f-NPs) with doxorubicin, tannic acid, curcumin, polyethylene glycol and their mixtures were determined using DLS, XRD, XPS and AES. The cytotoxicity of bare and f-NPs for various cell lines such as normal HEK-293 and cancer HeLa, MDA-MB-231, and MCF-7 was studied by MTT assay. Bare and f-NPs exhibited different cytotoxicity dependent on molecules bonding at the surface. Cytotoxicity increases with decreasing hydrodynamic diameter and increasing Zeta-potential, increasing content of lattice and adsorbed O2-, carboxyl groups and C vacancies, NH4+ groups, decreasing overlayer thickness, electron charge transfer to oxygen and more nucleophilic character of electron rich surface oxygen.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Surface Science

ISSN

0169-4332

e-ISSN

1873-5584

Svazek periodika

684

Číslo periodika v rámci svazku

Mar

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

14

Strana od-do

161873

Kód UT WoS článku

001406678800001

EID výsledku v databázi Scopus

2-s2.0-85210542253