Is GGAG:Ce@SiO2-RB composite a prospective material for X-ray induced photodynamic therapy?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00640829" target="_blank" >RIV/68378271:_____/25:00640829 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/25:00387981

Výsledek na webu

<a href="https://doi.org/10.1016/j.radphyschem.2025.112942" target="_blank" >https://doi.org/10.1016/j.radphyschem.2025.112942</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.radphyschem.2025.112942" target="_blank" >10.1016/j.radphyschem.2025.112942</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Is GGAG:Ce@SiO2-RB composite a prospective material for X-ray induced photodynamic therapy?

Popis výsledku v původním jazyce

Nanocomposite material (GGAG:Ce3+@SiO2-RB) for potential use in X-ray induced photodynamic therapy (X-PDT) was developed, thoroughly characterized, and evaluated. It consists of a scintillating Gd3(Ga1-xAlx)5O12:Ce3+ core encapsulated in silica layer and functionalized with the photosensitizer Rose Bengal (RB). Radioluminescence measurements confirmed the energy transfer from the scintillating core to Rose Bengal. Dark toxicity and radiosensitisation effects were evaluated using Saccharomyces cerevisiae as a model organism. The nanocomposite showed minimal dark toxicity at concentrations of up to 10 mg/mL. However, X-ray irradiation experiments did not demonstrate significant singlet oxygen production compared to the controls. Although the nanocomposite design shows potential, further optimization is needed to achieve an effective X-PDT performance.

Název v anglickém jazyce

Is GGAG:Ce@SiO2-RB composite a prospective material for X-ray induced photodynamic therapy?

Popis výsledku anglicky

Nanocomposite material (GGAG:Ce3+@SiO2-RB) for potential use in X-ray induced photodynamic therapy (X-PDT) was developed, thoroughly characterized, and evaluated. It consists of a scintillating Gd3(Ga1-xAlx)5O12:Ce3+ core encapsulated in silica layer and functionalized with the photosensitizer Rose Bengal (RB). Radioluminescence measurements confirmed the energy transfer from the scintillating core to Rose Bengal. Dark toxicity and radiosensitisation effects were evaluated using Saccharomyces cerevisiae as a model organism. The nanocomposite showed minimal dark toxicity at concentrations of up to 10 mg/mL. However, X-ray irradiation experiments did not demonstrate significant singlet oxygen production compared to the controls. Although the nanocomposite design shows potential, further optimization is needed to achieve an effective X-PDT performance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Physics and Chemistry

ISSN

0969-806X

e-ISSN

1879-0895

Svazek periodika

236

Číslo periodika v rámci svazku

Nov

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

112942

Kód UT WoS článku

001502108300002

EID výsledku v databázi Scopus

2-s2.0-105005871941