Deformation behaviour of a natural-shaped bone scaffold

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378297%3A_____%2F16%3A00461386" target="_blank" >RIV/68378297:_____/16:00461386 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21260/16:00300619

Výsledek na webu

<a href="http://mit.imt.si/Revija/izvodi/mit163/kytyr.pdf" target="_blank" >http://mit.imt.si/Revija/izvodi/mit163/kytyr.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17222/mit.2014.190" target="_blank" >10.17222/mit.2014.190</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deformation behaviour of a natural-shaped bone scaffold

Popis výsledku v původním jazyce

The study aims at mechanical testing of an artificial bone structure in the form of a scaffold for the application in the repairs of trabecular bones after wounds or degenerative diseases. Such artificial construct has to conform to many requirements including biocompatibility, permeability properties and bone-integration characteristics. Recently, self-degradable bone scaffolds suitable for natural-bone-tissue ingrowth optimized with respect to mechanical properties and body-fluid flow have been considered as an alternative to allografts and autografts. Here, an analysis of deformation behaviour of a scaffold with a morphology identical to the natural bone is the first step in this task. In this work, the geometry and morphology of scaffold specimens produced with direct 3D printing were based on a 3D model derived from the X-ray-computed micro-tomography measurement of a real trabecular bone. The geometrical model was upscaled four times in order to achieve the optimum ratio between its resolution and the resolution of the 3D printer. For its biocompatibility and self-degradability, polylactic acid was used as the printing material. The mechanical characteristics were obtained from a series of uniaxial compression tests, with an optical evaluation of the strain field on the surfaces of the specimens. The acquired stress-strain curves were compared with the characteristics of a real trabecular bone obtained with time-lapse microtomography measurements, evaluated with the digital volumetric correlation method. The results show good correspondence of the stiffness values for both the natural and artificial bone specimens.

Název v anglickém jazyce

Deformation behaviour of a natural-shaped bone scaffold

Popis výsledku anglicky

The study aims at mechanical testing of an artificial bone structure in the form of a scaffold for the application in the repairs of trabecular bones after wounds or degenerative diseases. Such artificial construct has to conform to many requirements including biocompatibility, permeability properties and bone-integration characteristics. Recently, self-degradable bone scaffolds suitable for natural-bone-tissue ingrowth optimized with respect to mechanical properties and body-fluid flow have been considered as an alternative to allografts and autografts. Here, an analysis of deformation behaviour of a scaffold with a morphology identical to the natural bone is the first step in this task. In this work, the geometry and morphology of scaffold specimens produced with direct 3D printing were based on a 3D model derived from the X-ray-computed micro-tomography measurement of a real trabecular bone. The geometrical model was upscaled four times in order to achieve the optimum ratio between its resolution and the resolution of the 3D printer. For its biocompatibility and self-degradability, polylactic acid was used as the printing material. The mechanical characteristics were obtained from a series of uniaxial compression tests, with an optical evaluation of the strain field on the surfaces of the specimens. The acquired stress-strain curves were compared with the characteristics of a real trabecular bone obtained with time-lapse microtomography measurements, evaluated with the digital volumetric correlation method. The results show good correspondence of the stiffness values for both the natural and artificial bone specimens.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JJ - Ostatní materiály

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials and Technology

ISSN

1580-2949

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

SI - Slovinská republika

Počet stran výsledku

5

Strana od-do

301-305

Kód UT WoS článku

000385008500003

EID výsledku v databázi Scopus

2-s2.0-84975066518