Influence of surface roughness of carbon materials on human osteoblast-like cell growth

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F14%3A00218358" target="_blank" >RIV/68407700:21220/14:00218358 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/14:00428950

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jbm.a.34833" target="_blank" >http://dx.doi.org/10.1002/jbm.a.34833</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.a.34833" target="_blank" >10.1002/jbm.a.34833</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of surface roughness of carbon materials on human osteoblast-like cell growth

Popis výsledku v původním jazyce

This article presents a study of the dependence of the biocompatibility of a carbon-based material, namely a 2D C/C composite, on mechanical and chemical surface modifications. The mechanical modifications were surface grinding and polishing, and chemical modifications were made by depositing thin layers of pyrolytic carbon, titanium-carbon and DLC layers. Human osteoblast-like MG 63 cells were cultivated on these materials. The densities of the cells after one-day cultivation and after four-day cultivation, and the average cell spreading area after one-day cultivation, were evaluated in dependence on particular surface roughness parameters. The minima of the cell density on pyrolytic carbon and titanium-carbon layers were found; they were connected with the maxima of the average cell area. For DLC, the cell area decreased as the roughness parameter Ra increased in the range 0.1-10 mu m, although the minimum appeared for the density of the cells. Using a multivariate test, the dependen

Název v anglickém jazyce

Influence of surface roughness of carbon materials on human osteoblast-like cell growth

Popis výsledku anglicky

This article presents a study of the dependence of the biocompatibility of a carbon-based material, namely a 2D C/C composite, on mechanical and chemical surface modifications. The mechanical modifications were surface grinding and polishing, and chemical modifications were made by depositing thin layers of pyrolytic carbon, titanium-carbon and DLC layers. Human osteoblast-like MG 63 cells were cultivated on these materials. The densities of the cells after one-day cultivation and after four-day cultivation, and the average cell spreading area after one-day cultivation, were evaluated in dependence on particular surface roughness parameters. The minima of the cell density on pyrolytic carbon and titanium-carbon layers were found; they were connected with the maxima of the average cell area. For DLC, the cell area decreased as the roughness parameter Ra increased in the range 0.1-10 mu m, although the minimum appeared for the density of the cells. Using a multivariate test, the dependen

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biomedical Materials Research Part A

ISSN

1549-3296

e-ISSN

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Svazek periodika

102

Číslo periodika v rámci svazku

JUN 2014

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

1868-1879

Kód UT WoS článku

000334488800025

EID výsledku v databázi Scopus

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