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Pressure Pulse Wave Velocity and Axial Prestretch in Arteries

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F19%3A00321866" target="_blank" >RIV/68407700:21220/19:00321866 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://doi.org/10.1007/978-981-10-9038-7_123" target="_blank" >https://doi.org/10.1007/978-981-10-9038-7_123</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/978-981-10-9038-7_123" target="_blank" >10.1007/978-981-10-9038-7_123</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Pressure Pulse Wave Velocity and Axial Prestretch in Arteries

  • Popis výsledku v původním jazyce

    The velocity of the propagation of a pressure pulse wave is considered to be a useful marker of the state of health of the cardiovascular system. Many clinical measurements, laboratory experiments and computational simulations have proved that the pressure pulse velocity correlates with age-related changes in the mechanical properties of arteries. Age-related stiffening of arteries, referred to as arteriosclerosis, leads to the increase in the pressure pulse velocity. However, the stress and strain state of an artery is not given solely by its loading and mechanical properties. Arteries are residually stressed that can be seen when cylindrical segment of an artery is excised from the body. The segment retracts because the axial prestretch is released. This prestretch declines with age, as a consequence of the damage accumulated to elastic lamellae during aging. Previous studies have paid little attention to the effect of axial prestretch on the velocity of the pressure pulse wave. The study presented here is based on a combination of a linearized 1D model of the fluid dynamics and the nonlinear anisotropic response of the human abdominal aorta. The model predicts that the application of axial prestretch can significantly change the velocity of the pressure pulse. To be more specific, preliminary results suggest that within the range of physiological pressures, the model that considers initial axial stretch of the aorta predicts lower pressure pulse velocity in comparison with the model that neglects axial prestrain of the tube.

  • Název v anglickém jazyce

    Pressure Pulse Wave Velocity and Axial Prestretch in Arteries

  • Popis výsledku anglicky

    The velocity of the propagation of a pressure pulse wave is considered to be a useful marker of the state of health of the cardiovascular system. Many clinical measurements, laboratory experiments and computational simulations have proved that the pressure pulse velocity correlates with age-related changes in the mechanical properties of arteries. Age-related stiffening of arteries, referred to as arteriosclerosis, leads to the increase in the pressure pulse velocity. However, the stress and strain state of an artery is not given solely by its loading and mechanical properties. Arteries are residually stressed that can be seen when cylindrical segment of an artery is excised from the body. The segment retracts because the axial prestretch is released. This prestretch declines with age, as a consequence of the damage accumulated to elastic lamellae during aging. Previous studies have paid little attention to the effect of axial prestretch on the velocity of the pressure pulse wave. The study presented here is based on a combination of a linearized 1D model of the fluid dynamics and the nonlinear anisotropic response of the human abdominal aorta. The model predicts that the application of axial prestretch can significantly change the velocity of the pressure pulse. To be more specific, preliminary results suggest that within the range of physiological pressures, the model that considers initial axial stretch of the aorta predicts lower pressure pulse velocity in comparison with the model that neglects axial prestrain of the tube.

Klasifikace

  • Druh

    D - Stať ve sborníku

  • CEP obor

  • OECD FORD obor

    20302 - Applied mechanics

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/GA18-26041S" target="_blank" >GA18-26041S: Vliv podélného předepnutí na mechanickou odezvu nelineárních elastických a viskoelastických trubic</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2019

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název statě ve sborníku

    World Congress on Medical Physics and Biomedical Engineering 2018

  • ISBN

    978-981-10-9038-7

  • ISSN

  • e-ISSN

    1680-0737

  • Počet stran výsledku

    5

  • Strana od-do

    665-669

  • Název nakladatele

    Springer Nature Singapore Pte Ltd.

  • Místo vydání

  • Místo konání akce

    Prague

  • Datum konání akce

    3. 6. 2018

  • Typ akce podle státní příslušnosti

    WRD - Celosvětová akce

  • Kód UT WoS článku

    000449742700123