In vitro exposure to complete engine emissions - a mini-review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F21%3A00352355" target="_blank" >RIV/68407700:21220/21:00352355 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/21:00551794

Výsledek na webu

<a href="https://doi.org/10.1016/j.tox.2021.152953" target="_blank" >https://doi.org/10.1016/j.tox.2021.152953</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tox.2021.152953" target="_blank" >10.1016/j.tox.2021.152953</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro exposure to complete engine emissions - a mini-review

Popis výsledku v původním jazyce

Outdoor air pollution is classified as carcinogenic to humans and exposure to it contributes to increased incidence of various diseases, including cardiovascular, neurological or pulmonary disorders. Vehicle engine emissions represent a significant part of outdoor air pollutants, particularly in large cities with high population density. Considering the potentially negative health impacts of engine emissions exposure, the application of reliable test systems allowing assessment of the biological effects of these pollutants is crucial. The exposure systems should use relevant, preferably multicellular, cell models that are treated with the complete engine exhaust (i.e. a realistic mixture of particles, chemical compounds bound to them and gaseous phase) at the air-liquid interface. The controlled delivery and characterization of chemical and/or particle composition of the exhaust should be possible. In this mini-review we report on such exposure systems that have been developed to date. We focus on a brief description and technical characterization of the systems, and discuss the biological parameters detected following exposure to a gasoline/diesel exhaust. Finally, we summarize and compare findings from the individual systems, including their advantages/limitations.

Název v anglickém jazyce

In vitro exposure to complete engine emissions - a mini-review

Popis výsledku anglicky

Outdoor air pollution is classified as carcinogenic to humans and exposure to it contributes to increased incidence of various diseases, including cardiovascular, neurological or pulmonary disorders. Vehicle engine emissions represent a significant part of outdoor air pollutants, particularly in large cities with high population density. Considering the potentially negative health impacts of engine emissions exposure, the application of reliable test systems allowing assessment of the biological effects of these pollutants is crucial. The exposure systems should use relevant, preferably multicellular, cell models that are treated with the complete engine exhaust (i.e. a realistic mixture of particles, chemical compounds bound to them and gaseous phase) at the air-liquid interface. The controlled delivery and characterization of chemical and/or particle composition of the exhaust should be possible. In this mini-review we report on such exposure systems that have been developed to date. We focus on a brief description and technical characterization of the systems, and discuss the biological parameters detected following exposure to a gasoline/diesel exhaust. Finally, we summarize and compare findings from the individual systems, including their advantages/limitations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology

ISSN

0300-483X

e-ISSN

1879-3185

Svazek periodika

462

Číslo periodika v rámci svazku

152953

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

000703081200004

EID výsledku v databázi Scopus

2-s2.0-85115743041