Traction-separation law parameters for the description of age-related changes in the delamination strength of the human descending thoracic aorta

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F24%3A00376048" target="_blank" >RIV/68407700:21220/24:00376048 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/s10237-024-01871-1" target="_blank" >https://doi.org/10.1007/s10237-024-01871-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10237-024-01871-1" target="_blank" >10.1007/s10237-024-01871-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Traction-separation law parameters for the description of age-related changes in the delamination strength of the human descending thoracic aorta

Popis výsledku v původním jazyce

Aortic dissection is a life-threatening disease that consists in the development of a tear in the wall of the aorta. The initial tear propagates as a discontinuity leading to separation within the aortic wall, which can result in the creation of a so-called false lumen. A fatal threat occurs if the rupture extends through the whole thickness of the aortic wall, as blood may then leak. It is generally accepted that the dissection, which can sometime extend along the entire length of the aorta, propagates via a delamination mechanism. The aim of the present paper is to provide experimentally validated parameters of a mathematical model for the description of the wall’s cohesion. A model of the peeling experiment was built in Abaqus. The delamination interface was described by a piecewise linear traction-separation law. The bulk behavior of the aorta was assumed to be nonlinearly elastic, anisotropic, and incompressible. Our simulations resulted in estimates of the material parameters for the traction-separation law of the human descending thoracic aorta, which were obtained by minimizing the differences between the FEM predictions and the delamination force given by the regression of the peeling experiments. The results show that the stress at damage initiation, Tc, should be understood as an age-dependent quantity, and under the assumptions of our model this dependence can be expressed by linear regression as Tc = - 13.03.10-4.Age + 0.2485 if the crack front advances in the axial direction, and Tc = - 7.58.10-4.Age + 0.1897 if the crack front advances in the direction of the aortic circumference (Tc [MPa], Age [years]). Other model parameters were the stiffness K and the separation at failure, δf–δc (K = 0.5 MPa/mm, δf–δc = 0.1 mm). The material parameters provided by our study can be used in numerical simulations of the biomechanics of dissection propagation through the aorta especially when age-associated phenomena are studied.

Název v anglickém jazyce

Traction-separation law parameters for the description of age-related changes in the delamination strength of the human descending thoracic aorta

Popis výsledku anglicky

Aortic dissection is a life-threatening disease that consists in the development of a tear in the wall of the aorta. The initial tear propagates as a discontinuity leading to separation within the aortic wall, which can result in the creation of a so-called false lumen. A fatal threat occurs if the rupture extends through the whole thickness of the aortic wall, as blood may then leak. It is generally accepted that the dissection, which can sometime extend along the entire length of the aorta, propagates via a delamination mechanism. The aim of the present paper is to provide experimentally validated parameters of a mathematical model for the description of the wall’s cohesion. A model of the peeling experiment was built in Abaqus. The delamination interface was described by a piecewise linear traction-separation law. The bulk behavior of the aorta was assumed to be nonlinearly elastic, anisotropic, and incompressible. Our simulations resulted in estimates of the material parameters for the traction-separation law of the human descending thoracic aorta, which were obtained by minimizing the differences between the FEM predictions and the delamination force given by the regression of the peeling experiments. The results show that the stress at damage initiation, Tc, should be understood as an age-dependent quantity, and under the assumptions of our model this dependence can be expressed by linear regression as Tc = - 13.03.10-4.Age + 0.2485 if the crack front advances in the axial direction, and Tc = - 7.58.10-4.Age + 0.1897 if the crack front advances in the direction of the aortic circumference (Tc [MPa], Age [years]). Other model parameters were the stiffness K and the separation at failure, δf–δc (K = 0.5 MPa/mm, δf–δc = 0.1 mm). The material parameters provided by our study can be used in numerical simulations of the biomechanics of dissection propagation through the aorta especially when age-associated phenomena are studied.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20302 - Applied mechanics

Projekt

<a href="/cs/project/GA20-11186S" target="_blank" >GA20-11186S: Mechanika tepenné delaminace a šíření trhliny</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomechanics and Modeling in Mechanobiology

ISSN

1617-7959

e-ISSN

1617-7940

Svazek periodika

23

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

1837-1849

Kód UT WoS článku

001268904300001

EID výsledku v databázi Scopus

2-s2.0-85198104334