Repetitive TMS of the somatosensory cortex improves writer's cramp and enhances cortical activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F10%3A00168876" target="_blank" >RIV/68407700:21230/10:00168876 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/10:6832 RIV/00064165:_____/10:6832

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Repetitive TMS of the somatosensory cortex improves writer's cramp and enhances cortical activity

Popis výsledku v původním jazyce

We focused on the modulation of the primary somatosensory cortex (SI) induced by repetitive transcranial magnetic stimulation (rTMS) in order to improve symptoms of writer's cramp. Patients with writer's cramp were treated with 30-minute 1 Hz real- or sham-rTMS of the SI cortex every day for 5 days. 1.5 T fMRI was examined during simple hand movements. While in the pilot study the rTMS coil was navigated over the SI cortex, patients in the advanced study had the coil above the postcentral sulcus. Afterreal-rTMS, 4 pilot study patients and 10 advanced study patients experienced subjective and objective improvement in writing. Patients exhibited a rTMS-induced BOLD signal increase bilaterally in the SI cortex, posterior parietal cortex and in the supplementary motor area (P<0.001 corrected). After sham-rTMS, no BOLD signal changes were observed. In conclusion, 1 Hz rTMS of the SI cortex can improve writer's cramp while increasing the cortical activity in both hemispheres.

Název v anglickém jazyce

Repetitive TMS of the somatosensory cortex improves writer's cramp and enhances cortical activity

Popis výsledku anglicky

We focused on the modulation of the primary somatosensory cortex (SI) induced by repetitive transcranial magnetic stimulation (rTMS) in order to improve symptoms of writer's cramp. Patients with writer's cramp were treated with 30-minute 1 Hz real- or sham-rTMS of the SI cortex every day for 5 days. 1.5 T fMRI was examined during simple hand movements. While in the pilot study the rTMS coil was navigated over the SI cortex, patients in the advanced study had the coil above the postcentral sulcus. Afterreal-rTMS, 4 pilot study patients and 10 advanced study patients experienced subjective and objective improvement in writing. Patients exhibited a rTMS-induced BOLD signal increase bilaterally in the SI cortex, posterior parietal cortex and in the supplementary motor area (P<0.001 corrected). After sham-rTMS, no BOLD signal changes were observed. In conclusion, 1 Hz rTMS of the SI cortex can improve writer's cramp while increasing the cortical activity in both hemispheres.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/1M0567" target="_blank" >1M0567: Centrum aplikované kybernetiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

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Kód UT WoS článku

000288581900011

EID výsledku v databázi Scopus

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