Telemetry physical activity monitoring in minipig´s model of Huntington´s disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00233612" target="_blank" >RIV/68407700:21230/15:00233612 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.csnn.eu" target="_blank" >http://www.csnn.eu</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn20152s39" target="_blank" >10.14735/amcsnn20152s39</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Telemetry physical activity monitoring in minipig´s model of Huntington´s disease

Popis výsledku v původním jazyce

Animal models represent a key tool for Huntington´s disease (HD) research. During the last decade large animal models of Huntington´s disease have been established to improve knowledge of HD under large brain conditions. Transgenic minipig expressing N-terminal part of human huntingtin with 124CAG/CAA repeats seems to be very promising HD model. Its previous characterization has shown various phenotypes affecting subcellular, cellular as well as organ systems level. The goal of this study was to detectand analyze a pathological pattern in physical activity of transgenic (TgHD) boars at the age of three years using telemetry approach. Into the study we have included five TgHD and five wild type (WT) animals for comparison. The physical activity was measured by the telemetric system rodentPACK2 whereas transmitter was placed into the collar. The analysis have shown significant decrease of total acceleration representing physical activity in TgHD boars between 4:40 and 5:30 a.m. (after n

Název v anglickém jazyce

Telemetry physical activity monitoring in minipig´s model of Huntington´s disease

Popis výsledku anglicky

Animal models represent a key tool for Huntington´s disease (HD) research. During the last decade large animal models of Huntington´s disease have been established to improve knowledge of HD under large brain conditions. Transgenic minipig expressing N-terminal part of human huntingtin with 124CAG/CAA repeats seems to be very promising HD model. Its previous characterization has shown various phenotypes affecting subcellular, cellular as well as organ systems level. The goal of this study was to detectand analyze a pathological pattern in physical activity of transgenic (TgHD) boars at the age of three years using telemetry approach. Into the study we have included five TgHD and five wild type (WT) animals for comparison. The physical activity was measured by the telemetric system rodentPACK2 whereas transmitter was placed into the collar. The analysis have shown significant decrease of total acceleration representing physical activity in TgHD boars between 4:40 and 5:30 a.m. (after n

Druh

D - Stať ve sborníku

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

The 3rd Conference on Animal Models for Neurodegenerative Diseases - proceedings book

ISBN

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ISSN

1210-7859

e-ISSN

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Počet stran výsledku

4

Strana od-do

"2S39"-"2S42"

Název nakladatele

ČLS JEP

Místo vydání

Praha

Místo konání akce

Liblice

Datum konání akce

8. 11. 2015

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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