Perioperative tight glucose control reduces postoperative adverse events in non-diabetic cardiac surgery patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00233650" target="_blank" >RIV/68407700:21230/15:00233650 - isvavai.cz</a>

Výsledek na webu

<a href="http://press.endocrine.org/doi/abs/10.1210/jc.2015-1959" target="_blank" >http://press.endocrine.org/doi/abs/10.1210/jc.2015-1959</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/jc.2015-1959" target="_blank" >10.1210/jc.2015-1959</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Perioperative tight glucose control reduces postoperative adverse events in non-diabetic cardiac surgery patients

Popis výsledku v původním jazyce

Context: Tight glucose control (TGC) reduces morbidity and mortality in patients undergoing elective cardiac surgery, but only limited data about its optimal timing are available to date. Objective: To compare the effects of perioperative (PERI) versus postoperative (POST) initiation of TGC on postoperative adverse events in cardiac surgery patients. Design: Single center, single-blind, parallel-group, randomized controlled trial. Settings: Academic tertiary hospital. Participants: 2383 hemodynamicallystable patients undergoing major cardiac surgery with expected postoperative ICU treatment for at least 2 consecutive days. Intervention: Perioperatively or postoperatively initiated intensive insulin therapy with target glucose range 4.4?6.1 mmol/l. Main Outcome Measures: Adverse events from any cause during postoperative hospital stay. Results: In the whole cohort, perioperatively initiated TGC markedly reduced the number of postoperative complications (23.2 vs. 34.1%, 95% CI 0.60?0.78

Název v anglickém jazyce

Perioperative tight glucose control reduces postoperative adverse events in non-diabetic cardiac surgery patients

Popis výsledku anglicky

Context: Tight glucose control (TGC) reduces morbidity and mortality in patients undergoing elective cardiac surgery, but only limited data about its optimal timing are available to date. Objective: To compare the effects of perioperative (PERI) versus postoperative (POST) initiation of TGC on postoperative adverse events in cardiac surgery patients. Design: Single center, single-blind, parallel-group, randomized controlled trial. Settings: Academic tertiary hospital. Participants: 2383 hemodynamicallystable patients undergoing major cardiac surgery with expected postoperative ICU treatment for at least 2 consecutive days. Intervention: Perioperatively or postoperatively initiated intensive insulin therapy with target glucose range 4.4?6.1 mmol/l. Main Outcome Measures: Adverse events from any cause during postoperative hospital stay. Results: In the whole cohort, perioperatively initiated TGC markedly reduced the number of postoperative complications (23.2 vs. 34.1%, 95% CI 0.60?0.78

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JC - Počítačový hardware a software

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Clinical Endocrinology & Metabolism

ISSN

1945-7197

e-ISSN

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Svazek periodika

Volume 100

Číslo periodika v rámci svazku

Issue 8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

3081-3089

Kód UT WoS článku

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EID výsledku v databázi Scopus

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