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Detection of postural oscillatory movement without clinically manifested tremor in multiple sclerosis: A pilot study

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00233749" target="_blank" >RIV/68407700:21230/15:00233749 - isvavai.cz</a>

  • Výsledek na webu

    <a href="http://www.sciencedirect.com/science/article/pii/S1388245714007603" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1388245714007603</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clinph.2014.10.186" target="_blank" >10.1016/j.clinph.2014.10.186</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Detection of postural oscillatory movement without clinically manifested tremor in multiple sclerosis: A pilot study

  • Popis výsledku v původním jazyce

    Background Tremor is an involuntary rhythmic oscillatory movement of a body. It belongs to one of the most prevalent and disabling feature in multiple sclerosis (MS). Objectives The types of tremor in MS are still not unified. The aim of our work was to detect which types of oscillatory movements of upper extremities are present in MS without clinical manifestation of the tremor. Material and Methods Ten patients with MS (9 women, mean age 37 ± 11 years, mean EDSS 3,9 ± 0,8, mean length of the disease 10,2 ± 7,3) and 10 healthy controls participated in this study. Postural tremor was measured with open and closed eyes using an accelerometer LIS 3LV02DQ, ST Micro. The most complex resting signal was measured in upright position, when one arm was hanging freely next to the body and second arm was raised forward. Tremor sensor was placed on the index finger of arm that was raised forward. Frequency, rhythmicity and change of amplitudes were analyzed by spectral analysis. Results In healthy subjects with open eyes the spectral analysis showed 3 prevailing frequencies of oscillatory movements: (a) 2–3 Hz, (b) 7–10 Hz, and (c) 12–14 Hz. When eyes were closed, the lowest frequencies disappeared. Oscillatory movement of 7–10 Hz was the most frequent type in MS and significantly differs from healthy subjects. The amplitude of oscillatory movements in MS was profoundly higher than in healthy individuals. Conclusions Difference of frequency of oscillatory movements in MS with the most prominent manifestation at 7–10 Hz may correspond to early desinhibition of motor control probably at subcortical level.

  • Název v anglickém jazyce

    Detection of postural oscillatory movement without clinically manifested tremor in multiple sclerosis: A pilot study

  • Popis výsledku anglicky

    Background Tremor is an involuntary rhythmic oscillatory movement of a body. It belongs to one of the most prevalent and disabling feature in multiple sclerosis (MS). Objectives The types of tremor in MS are still not unified. The aim of our work was to detect which types of oscillatory movements of upper extremities are present in MS without clinical manifestation of the tremor. Material and Methods Ten patients with MS (9 women, mean age 37 ± 11 years, mean EDSS 3,9 ± 0,8, mean length of the disease 10,2 ± 7,3) and 10 healthy controls participated in this study. Postural tremor was measured with open and closed eyes using an accelerometer LIS 3LV02DQ, ST Micro. The most complex resting signal was measured in upright position, when one arm was hanging freely next to the body and second arm was raised forward. Tremor sensor was placed on the index finger of arm that was raised forward. Frequency, rhythmicity and change of amplitudes were analyzed by spectral analysis. Results In healthy subjects with open eyes the spectral analysis showed 3 prevailing frequencies of oscillatory movements: (a) 2–3 Hz, (b) 7–10 Hz, and (c) 12–14 Hz. When eyes were closed, the lowest frequencies disappeared. Oscillatory movement of 7–10 Hz was the most frequent type in MS and significantly differs from healthy subjects. The amplitude of oscillatory movements in MS was profoundly higher than in healthy individuals. Conclusions Difference of frequency of oscillatory movements in MS with the most prominent manifestation at 7–10 Hz may correspond to early desinhibition of motor control probably at subcortical level.

Klasifikace

  • Druh

    O - Ostatní výsledky

  • CEP obor

    JA - Elektronika a optoelektronika, elektrotechnika

  • OECD FORD obor

Návaznosti výsledku

  • Projekt

  • Návaznosti

    S - Specificky vyzkum na vysokych skolach

Ostatní

  • Rok uplatnění

    2015

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů