Connectivity changes in epileptic network at the seizure onset

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F16%3A00304661" target="_blank" >RIV/68407700:21230/16:00304661 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/epi.13609/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/epi.13609/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/epi.13609" target="_blank" >10.1111/epi.13609</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Connectivity changes in epileptic network at the seizure onset

Popis výsledku v původním jazyce

Purpose: Interaction between seizure onset zone (SOZ) and remaining epileptic network is still unclear. Recent studies have demonstrated dynamical reconfiguration of functional network connectivity at the seizure onset, particularly within the SOZ, but with inconsistent results. Method: In this study we explored the effective connectivity changes in intracranial EEG recordings from eight patients with refractory neocortical epilepsy. The detailed connectivity was represented by direct Directed Transfer Function (dDTF) that was optimized for short-time high-frequency resolution to analyse 36 seizures. Dynamics of the connectivity was tested between the whole SOZ and surrounding network (global view) and also between pairs of contacts within zones (local view) in the first seconds before and after seizure onset. Results: High specific decrease in effective connectivity in frequency range around 50-150 Hz was revealed in SOZ during early seizure states. However, common increase in energy and decrease in coherency reflected activation of the SOZ, not the disconnection from surrounding network. The high-amplitude propagated activity was observed in frequencies up to 100 Hz without connectivity changes. Conclusion: The presented results suggest that SOZ is characterized by activation of SOZ, predominantly in 50-150 Hz range, and this is characterised by decrease in connectivity. In addition the changes of the global connectivity in transition from pre-ictal to ictal state were highly specific marker for SOZ localization.

Název v anglickém jazyce

Connectivity changes in epileptic network at the seizure onset

Popis výsledku anglicky

Purpose: Interaction between seizure onset zone (SOZ) and remaining epileptic network is still unclear. Recent studies have demonstrated dynamical reconfiguration of functional network connectivity at the seizure onset, particularly within the SOZ, but with inconsistent results. Method: In this study we explored the effective connectivity changes in intracranial EEG recordings from eight patients with refractory neocortical epilepsy. The detailed connectivity was represented by direct Directed Transfer Function (dDTF) that was optimized for short-time high-frequency resolution to analyse 36 seizures. Dynamics of the connectivity was tested between the whole SOZ and surrounding network (global view) and also between pairs of contacts within zones (local view) in the first seconds before and after seizure onset. Results: High specific decrease in effective connectivity in frequency range around 50-150 Hz was revealed in SOZ during early seizure states. However, common increase in energy and decrease in coherency reflected activation of the SOZ, not the disconnection from surrounding network. The high-amplitude propagated activity was observed in frequencies up to 100 Hz without connectivity changes. Conclusion: The presented results suggest that SOZ is characterized by activation of SOZ, predominantly in 50-150 Hz range, and this is characterised by decrease in connectivity. In addition the changes of the global connectivity in transition from pre-ictal to ictal state were highly specific marker for SOZ localization.

Druh

O - Ostatní výsledky

CEP obor

JA - Elektronika a optoelektronika, elektrotechnika

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů