Comparative analysis of upper limb motor function and articulation disorder in Parkinson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F16%3A00305784" target="_blank" >RIV/68407700:21230/16:00305784 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21460/16:00305784

Výsledek na webu

<a href="http://www.mdsabstracts.org/abstract/comparative-analysis-of-upper-limb-motor-function-and-articulation-disorder-in-parkinsons-disease/" target="_blank" >http://www.mdsabstracts.org/abstract/comparative-analysis-of-upper-limb-motor-function-and-articulation-disorder-in-parkinsons-disease/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparative analysis of upper limb motor function and articulation disorder in Parkinson's disease

Popis výsledku v původním jazyce

Objective: To assess the relationship between upper limb bradykinesia and hypokinetic dysarthria in Parkinson’s disease (PD) using instrumental investigations of speech and limb motor function. Background: Hypokinetic dysarthria in PD has been traditionally attributed to bradykinesia of the laryngeal muscles. However, the majority of previous studies failed to find a direct connection between speech abnormalities and limb bradykinesia. Methods: 22 patients (10 M, 12 F), mean age 64 (48-82) yrs, with mild to moderate PD, mean Hoehn & Yahr stage 2 (range 1-2.5), disease duration 9.3 (1-24) yrs, participated to the study. The finger tapping subtest of the Halstead-Reitan neuropsychological battery (HRFT), Purdue Pegboard Test (PPT), Bradykinesia-Akinesia Incoordination Test (BT), and expert ratings of videotaped finger tapping according to MDS-UPDRS were performed to measure manual dexterity and motor slowing. To acoustically investigate speech, two articulation measures of vowel space area (VSA, representing precision of vowel articulation) and number of pauses (NoP, representing precision of stop consonants articulation) were extracted from the monologue task. Spearman correlations were applied, the level of significance was set to p< 0.01. Results: We found positive correlations between PPT and VSA (r = 0.58, p = 0.005) as well as between PPT and NoP (r = 0.55, p = 0.008). Positive correlation was also found between BT and NoP (r = 0.56, p = 0.006). No other significant associations between speech and limb function were seen. Admittedly, performance in PPT was related to performance in BT (r = 0.61, p< 0.001). Conclusions: The associations we found between deterioration in PPT and BT performances and decline in precision of vowel and consonant articulation indicate that bradykinesia and hypokinetic dysarthria in PD share similar pathophysiological mechanisms.

Název v anglickém jazyce

Comparative analysis of upper limb motor function and articulation disorder in Parkinson's disease

Popis výsledku anglicky

Objective: To assess the relationship between upper limb bradykinesia and hypokinetic dysarthria in Parkinson’s disease (PD) using instrumental investigations of speech and limb motor function. Background: Hypokinetic dysarthria in PD has been traditionally attributed to bradykinesia of the laryngeal muscles. However, the majority of previous studies failed to find a direct connection between speech abnormalities and limb bradykinesia. Methods: 22 patients (10 M, 12 F), mean age 64 (48-82) yrs, with mild to moderate PD, mean Hoehn & Yahr stage 2 (range 1-2.5), disease duration 9.3 (1-24) yrs, participated to the study. The finger tapping subtest of the Halstead-Reitan neuropsychological battery (HRFT), Purdue Pegboard Test (PPT), Bradykinesia-Akinesia Incoordination Test (BT), and expert ratings of videotaped finger tapping according to MDS-UPDRS were performed to measure manual dexterity and motor slowing. To acoustically investigate speech, two articulation measures of vowel space area (VSA, representing precision of vowel articulation) and number of pauses (NoP, representing precision of stop consonants articulation) were extracted from the monologue task. Spearman correlations were applied, the level of significance was set to p< 0.01. Results: We found positive correlations between PPT and VSA (r = 0.58, p = 0.005) as well as between PPT and NoP (r = 0.55, p = 0.008). Positive correlation was also found between BT and NoP (r = 0.56, p = 0.006). No other significant associations between speech and limb function were seen. Admittedly, performance in PPT was related to performance in BT (r = 0.61, p< 0.001). Conclusions: The associations we found between deterioration in PPT and BT performances and decline in precision of vowel and consonant articulation indicate that bradykinesia and hypokinetic dysarthria in PD share similar pathophysiological mechanisms.

Druh

O - Ostatní výsledky

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů