miXGENE: an Effective Public Tool for Integrative Analysis of High-throuhput Omics Data

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F16%3A00306177" target="_blank" >RIV/68407700:21230/16:00306177 - isvavai.cz</a>

Výsledek na webu

<a href="https://wikt-daz2016.fiit.stuba.sk/wp-content/uploads/2016/11/WIKT-DaZ-2016_Proceedings.pdf" target="_blank" >https://wikt-daz2016.fiit.stuba.sk/wp-content/uploads/2016/11/WIKT-DaZ-2016_Proceedings.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

miXGENE: an Effective Public Tool for Integrative Analysis of High-throuhput Omics Data

Popis výsledku v původním jazyce

Molecular biology is a domain endowed by a good amount of data and well-formalized knowledge. Based on measured data and domain knowledge, an intelligent integrative analysis is capable of extracting new and more specific knowledge, which may help to comprehension of e.g. disease mechanisms. We have proposed miXGENE, a web service for integrating and analyzing high-throughput omics data, namely from the microarray-based expression or methylation measurements, together with formal biological knowledge, such as gene ontologies and curated or predicted omics interactions. The tool enables building the most employed analytical workflows for processing user-data or the data from public databases. Processing of the data is followed by their integrative statistical or machine-learning based analysis, and completed with the presentation of results in the expert-comprehensible terms. We propose an innovation of the tool which profits from the infrastructure of the Czech National Grid, CESNET – MetaCentrum, which facilitates the most computationally demanding sections.

Název v anglickém jazyce

miXGENE: an Effective Public Tool for Integrative Analysis of High-throuhput Omics Data

Popis výsledku anglicky

Molecular biology is a domain endowed by a good amount of data and well-formalized knowledge. Based on measured data and domain knowledge, an intelligent integrative analysis is capable of extracting new and more specific knowledge, which may help to comprehension of e.g. disease mechanisms. We have proposed miXGENE, a web service for integrating and analyzing high-throughput omics data, namely from the microarray-based expression or methylation measurements, together with formal biological knowledge, such as gene ontologies and curated or predicted omics interactions. The tool enables building the most employed analytical workflows for processing user-data or the data from public databases. Processing of the data is followed by their integrative statistical or machine-learning based analysis, and completed with the presentation of results in the expert-comprehensible terms. We propose an innovation of the tool which profits from the infrastructure of the Czech National Grid, CESNET – MetaCentrum, which facilitates the most computationally demanding sections.

Druh

D - Stať ve sborníku

CEP obor

IN - Informatika

OECD FORD obor

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Projekt

<a href="/cs/project/NT14377" target="_blank" >NT14377: Predikce odpovědi na demetylační léčbu u pacientů s myelodysplastickým syndromem s využitím integrativní genomiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings in Informatics and Information Technologies - (WIKT & DaZ 2016) 11th Workshop on Intelligent and Knowledge Oriented Technologies 35th Conference on Data and Knowledge

ISBN

978-80-227-4619-9

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

271-274

Název nakladatele

Vydavatel'stvo STU

Místo vydání

Bratislava

Místo konání akce

Smolenice

Datum konání akce

3. 11. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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