Lacosamide And Levetiracetam Have No Effect On Sharp-Wave Ripple Rate

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lacosamide And Levetiracetam Have No Effect On Sharp-Wave Ripple Rate

Popis výsledku v původním jazyce

Purpose:Pathological high-frequency oscillations (HFOs)are a novel marker used to improve the delineation ofepileptogenic tissue and, hence, the outcome of epilepsysurgery. Their clinical utilization is curtailed by the inabil-ity to discriminate them from physiological HFOs due tofrequency overlap. Although it is well documented thatpathological HFOs are suppressed by antiepileptic drugs,the effect of antiepileptic drugs on physiological HFOs is not well known. In this experimental study, we haveexplored whether hippocampal sharp-wave ripples (SWRs),a representative of physiological HFOs, respond to AEDtreatment. Method:Eleven adult male rats were implanted withrecording electrodes into the dorsal hippocampi and video-EEG monitored for 4 weeks continuously. Each animalreceived injections of levetiracetam, lacosamide and salinein 3-day intervals in random order. SWRs were detectedusing root mean square (RMS)-based detector. Then, wecalculated ratios of SWR rate after levetiracetam or lacosa-mide injection to the rate after saline injection. Medians ofthese ratios were compared to unity using non-parametricconfidence interval technique. The equality margins wereset to 0.75 and 1.25.Results:The confidence intervals for levetiracetam did notcross the equality margins. Lacosamide caused slightincrease of SWR rate (Wilcoxon test p = 0.039), comparedto saline.Conclusion:The results show that application of a singledose of levetiracetam or lacosamide does not reduce theSWR rate which gives these drugs the potential for phar-macological test distinguishing pathological and physiologi-cal HFOs. In addition, it seems that these new generationdrugs do not negatively affect the cellular and networkmechanisms involved in sharp-wave ripple generation,which may provide a plausible explanation for the absenceof significant negative effects on cognitive functions ofthese drugs, particularly on memory.

Název v anglickém jazyce

Lacosamide And Levetiracetam Have No Effect On Sharp-Wave Ripple Rate

Popis výsledku anglicky

Purpose:Pathological high-frequency oscillations (HFOs)are a novel marker used to improve the delineation ofepileptogenic tissue and, hence, the outcome of epilepsysurgery. Their clinical utilization is curtailed by the inabil-ity to discriminate them from physiological HFOs due tofrequency overlap. Although it is well documented thatpathological HFOs are suppressed by antiepileptic drugs,the effect of antiepileptic drugs on physiological HFOs is not well known. In this experimental study, we haveexplored whether hippocampal sharp-wave ripples (SWRs),a representative of physiological HFOs, respond to AEDtreatment. Method:Eleven adult male rats were implanted withrecording electrodes into the dorsal hippocampi and video-EEG monitored for 4 weeks continuously. Each animalreceived injections of levetiracetam, lacosamide and salinein 3-day intervals in random order. SWRs were detectedusing root mean square (RMS)-based detector. Then, wecalculated ratios of SWR rate after levetiracetam or lacosa-mide injection to the rate after saline injection. Medians ofthese ratios were compared to unity using non-parametricconfidence interval technique. The equality margins wereset to 0.75 and 1.25.Results:The confidence intervals for levetiracetam did notcross the equality margins. Lacosamide caused slightincrease of SWR rate (Wilcoxon test p = 0.039), comparedto saline.Conclusion:The results show that application of a singledose of levetiracetam or lacosamide does not reduce theSWR rate which gives these drugs the potential for phar-macological test distinguishing pathological and physiologi-cal HFOs. In addition, it seems that these new generationdrugs do not negatively affect the cellular and networkmechanisms involved in sharp-wave ripple generation,which may provide a plausible explanation for the absenceof significant negative effects on cognitive functions ofthese drugs, particularly on memory.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů