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Directional microwave ablation: Experimental evaluation of a 2.45 GHz applicator in ex vivo and in vivo liver

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F20%3A00339323" target="_blank" >RIV/68407700:21230/20:00339323 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://doi.org/10.1016/j.jvir.2020.01.016" target="_blank" >https://doi.org/10.1016/j.jvir.2020.01.016</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jvir.2020.01.016" target="_blank" >10.1016/j.jvir.2020.01.016</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Directional microwave ablation: Experimental evaluation of a 2.45 GHz applicator in ex vivo and in vivo liver

  • Popis výsledku v původním jazyce

    Purpose To experimentally characterize a microwave (MW) ablation applicator designed to produce directional ablation zones. Materials and Methods Using a 14-gauge, 2.45-GHz side-firing MW ablation applicator, 36 ex vivo bovine liver ablations were performed. Ablations were performed at 60 W, 80 W, and 100 W for 3, 5, and 10 minutes (n = 4 per combination). Ablation zone forward and backward depth and width were measured and directivity was calculated as the ratio of forward to backward depth. Thirteen in vivo ablations were performed in 2 domestic swine with the applicator either inserted into the liver (80 W, 5 min, n = 3; 100 W, 5 min, n = 3; 100 W, 10 min, n = 2) or placed on the surface of the liver with a nontarget tissue placed on the back side of the applicator (80 W, 5 min, n = 5). The animals were immediately euthanized after the procedure; the livers were harvested and sectioned perpendicular to the axis of the applicator. In vivo ablation zones were measured following viability staining and assessed on histopathology. Results Mean ex vivo ablation forward depth was 8.3–15.5 mm. No backward heating was observed at 60 W, 3–5 minutes; directivity was 4.7–11.0 for the other power and time combinations. In vivo ablation forward depth was 10.3–11.5 mm, and directivity was 11.5–16.1. No visible or microscopic thermal damage to nontarget tissues in direct contact with the back side of the applicator was observed. Conclusions The side-firing MW ablation applicator can create directional ablation zones in ex vivo and in vivo tissues.

  • Název v anglickém jazyce

    Directional microwave ablation: Experimental evaluation of a 2.45 GHz applicator in ex vivo and in vivo liver

  • Popis výsledku anglicky

    Purpose To experimentally characterize a microwave (MW) ablation applicator designed to produce directional ablation zones. Materials and Methods Using a 14-gauge, 2.45-GHz side-firing MW ablation applicator, 36 ex vivo bovine liver ablations were performed. Ablations were performed at 60 W, 80 W, and 100 W for 3, 5, and 10 minutes (n = 4 per combination). Ablation zone forward and backward depth and width were measured and directivity was calculated as the ratio of forward to backward depth. Thirteen in vivo ablations were performed in 2 domestic swine with the applicator either inserted into the liver (80 W, 5 min, n = 3; 100 W, 5 min, n = 3; 100 W, 10 min, n = 2) or placed on the surface of the liver with a nontarget tissue placed on the back side of the applicator (80 W, 5 min, n = 5). The animals were immediately euthanized after the procedure; the livers were harvested and sectioned perpendicular to the axis of the applicator. In vivo ablation zones were measured following viability staining and assessed on histopathology. Results Mean ex vivo ablation forward depth was 8.3–15.5 mm. No backward heating was observed at 60 W, 3–5 minutes; directivity was 4.7–11.0 for the other power and time combinations. In vivo ablation forward depth was 10.3–11.5 mm, and directivity was 11.5–16.1. No visible or microscopic thermal damage to nontarget tissues in direct contact with the back side of the applicator was observed. Conclusions The side-firing MW ablation applicator can create directional ablation zones in ex vivo and in vivo tissues.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    20601 - Medical engineering

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/EF16_019%2F0000765" target="_blank" >EF16_019/0000765: Výzkumné centrum informatiky</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of Vascular and Interventional Radiology

  • ISSN

    1051-0443

  • e-ISSN

    1535-7732

  • Svazek periodika

    31

  • Číslo periodika v rámci svazku

    7

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    8

  • Strana od-do

    1170-1177

  • Kód UT WoS článku

    000542580500024

  • EID výsledku v databázi Scopus

    2-s2.0-85081926413