Validation of cepstral peak prominence in assessing early voice changes of Parkinson’s disease: effect of speaking task and ambient noise.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F21%3A00353824" target="_blank" >RIV/68407700:21230/21:00353824 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10436627

Výsledek na webu

<a href="https://doi.org/10.1121/10.0009063" target="_blank" >https://doi.org/10.1121/10.0009063</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1121/10.0009063" target="_blank" >10.1121/10.0009063</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Validation of cepstral peak prominence in assessing early voice changes of Parkinson’s disease: effect of speaking task and ambient noise.

Popis výsledku v původním jazyce

Although cepstral peak prominence (CPP) and its smooth variant (CPPS) are considered robust acoustic measures for the evaluation of dysphonia, whether they are sensitive to capture early voice changes in Parkinson’s disease (PD) has not yet been explored. This study aimed to investigate voice changes via CPP measures in idiopathic rapid eye movement sleep disorder behaviour (iRBD), a special case of prodromal neurodegeneration, and in both newly diagnosed, and advanced-stage PD patients using different speaking tasks across noise-free and noisy environments. The sustained vowel phonation, the reading of passages and the monologues of 60 early-stage untreated PD, 30 advanced-stage PD, 60 iRBD, and 60 healthy control (HC) participants were evaluated. We found significant differences between both PD groups and the controls in sustained phonation via CPP (p < 0.05) and CPPS (p < 0.01) and in monologue via CPP (p < 0.01), although neither CPP nor CPPS measures were sufficiently sensitive to capture possible prodromal dysphonia in iRBD. The quality of both CPP and CPPS measures was influenced substantially by the addition of ambient noise. We anticipated that CPP measures might serve as a promising digital biomarker in assessing dysphonia from the early stages of PD.

Název v anglickém jazyce

Validation of cepstral peak prominence in assessing early voice changes of Parkinson’s disease: effect of speaking task and ambient noise.

Popis výsledku anglicky

Although cepstral peak prominence (CPP) and its smooth variant (CPPS) are considered robust acoustic measures for the evaluation of dysphonia, whether they are sensitive to capture early voice changes in Parkinson’s disease (PD) has not yet been explored. This study aimed to investigate voice changes via CPP measures in idiopathic rapid eye movement sleep disorder behaviour (iRBD), a special case of prodromal neurodegeneration, and in both newly diagnosed, and advanced-stage PD patients using different speaking tasks across noise-free and noisy environments. The sustained vowel phonation, the reading of passages and the monologues of 60 early-stage untreated PD, 30 advanced-stage PD, 60 iRBD, and 60 healthy control (HC) participants were evaluated. We found significant differences between both PD groups and the controls in sustained phonation via CPP (p < 0.05) and CPPS (p < 0.01) and in monologue via CPP (p < 0.01), although neither CPP nor CPPS measures were sufficiently sensitive to capture possible prodromal dysphonia in iRBD. The quality of both CPP and CPPS measures was influenced substantially by the addition of ambient noise. We anticipated that CPP measures might serve as a promising digital biomarker in assessing dysphonia from the early stages of PD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of the Acoustical Society of America

ISSN

0001-4966

e-ISSN

1520-8524

Svazek periodika

150

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

4522-4533

Kód UT WoS článku

000739073700005

EID výsledku v databázi Scopus

2-s2.0-85122543986