AFM-IN-SEM ANALYSES OF THIORPHAN ASSEMBLY ON ZNO POLAR AND NONPOLAR SURFACES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F24%3A00377645" target="_blank" >RIV/68407700:21230/24:00377645 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.37904/nanocon.2023.4761" target="_blank" >https://doi.org/10.37904/nanocon.2023.4761</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2023.4761" target="_blank" >10.37904/nanocon.2023.4761</a>

Jazyk výsledku

angličtina

Název v původním jazyce

AFM-IN-SEM ANALYSES OF THIORPHAN ASSEMBLY ON ZNO POLAR AND NONPOLAR SURFACES

Popis výsledku v původním jazyce

Despite the importance of thiorphan as a small molecule with vital biological roles, its interactions with zinc oxide (ZnO) nanomaterials that are prospective in drug delivery and theranostic applications have not yet been sufficiently explored. Here the impact of surface polarity of different ZnO surfaces on thiorphan adsorption is studied experimentally by combined in-situ scanning electron microscope (SEM) and atomic force microscope (AFM). Polar ZnO surfaces cause formation of thiorphan nanodots ( 4 nm or 25 nm), where the size of the nanodots depends on the direction of the surface dipoles. Nonpolar ZnO surfaces cause self-assembly of thiorphan into nanoislands and nanolayers with characteristic 4 nm layer thickness. AFM-in-SEM data shows clear correlation between secondary electron intensity of molecules in SEM and their height in AFM on polar ZnO surface whereas anti-correlation is observed on nonpolar ZnO surface. The secondary electron emission from the same molecule thus depends on its orientation, structure it assembles into and it can be controlled by direction of the substrate surface dipole.

Název v anglickém jazyce

AFM-IN-SEM ANALYSES OF THIORPHAN ASSEMBLY ON ZNO POLAR AND NONPOLAR SURFACES

Popis výsledku anglicky

Despite the importance of thiorphan as a small molecule with vital biological roles, its interactions with zinc oxide (ZnO) nanomaterials that are prospective in drug delivery and theranostic applications have not yet been sufficiently explored. Here the impact of surface polarity of different ZnO surfaces on thiorphan adsorption is studied experimentally by combined in-situ scanning electron microscope (SEM) and atomic force microscope (AFM). Polar ZnO surfaces cause formation of thiorphan nanodots ( 4 nm or 25 nm), where the size of the nanodots depends on the direction of the surface dipoles. Nonpolar ZnO surfaces cause self-assembly of thiorphan into nanoislands and nanolayers with characteristic 4 nm layer thickness. AFM-in-SEM data shows clear correlation between secondary electron intensity of molecules in SEM and their height in AFM on polar ZnO surface whereas anti-correlation is observed on nonpolar ZnO surface. The secondary electron emission from the same molecule thus depends on its orientation, structure it assembles into and it can be controlled by direction of the substrate surface dipole.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

<a href="/cs/project/TM03000033" target="_blank" >TM03000033: TACOM - Vývoj korelativního AFM a SEM/AirSEM mikroskopu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2023 Conference Proceedings

ISBN

978-80-88365-15-0

ISSN

2694-930X

e-ISSN

—

Počet stran výsledku

8

Strana od-do

360-367

Název nakladatele

TANGER

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

18. 10. 2023

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

001234125400057