Production of the positron-emitting radionuclide 68Ga: the radiochemical scheme of radionuclide generator 68Ge -> 68Ga

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F18%3A00322981" target="_blank" >RIV/68407700:21340/18:00322981 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.15328/cb1003" target="_blank" >http://dx.doi.org/10.15328/cb1003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15328/cb1003" target="_blank" >10.15328/cb1003</a>

Jazyk výsledku

ruština

Název v původním jazyce

Получение позитрон-излучающего радионуклида 68Ga: радиохимическая схема радионуклидного генератора 68Ge -> 68Ga

Popis výsledku v původním jazyce

68Ga (T1 / 2 = 68 min) in complexes with peptides is used in positron emission tomography for diagnostics of neuroendocrine tumors. The most promising strategy for 68Ga production is usage of the radionuclide generator 68Ge -> 68Ga. In this research, the sorption behavior of Ge(IV) and Ga (III) has been studied. The distribution coefficients (Kd) of Ge(IV) on the anion exchange (Dowex 1x8) and cation exchange (Dowex 50x8) resins in various ethanedioic and hydrochloric acid solutions were determined. For each ion exchange resin, four series of measurements were carried out, in which the concentration of oxalic acid was fixed (0.001 M, 0.003 M, 0.005 M, 0.01 M), and the concentrations of hydrochloric acid ranged from 0 to 3 M. Based on the distribution coefficients, the chemical scheme of the radionuclide generator 68Ge -> 68Ga has been developed. The chemical system is based on the anion exchange resin Dowex 1x8 and mixture of 0.005 M C2H2O4 / 0.33 M HCl. Several types of the generators with direct and reverse mode of elution were tested and the optimal scheme was determined. Elution of the generators was performed once a day with 8 ml of 0.005 M C2H2O4 / 0.33 M HCl solution. The 68Ga yield and the 68Ge breakthrough are comparable for all the systems.

Název v anglickém jazyce

Production of the positron-emitting radionuclide 68Ga: the radiochemical scheme of radionuclide generator 68Ge -> 68Ga

Popis výsledku anglicky

68Ga (T1 / 2 = 68 min) in complexes with peptides is used in positron emission tomography for diagnostics of neuroendocrine tumors. The most promising strategy for 68Ga production is usage of the radionuclide generator 68Ge -> 68Ga. In this research, the sorption behavior of Ge(IV) and Ga (III) has been studied. The distribution coefficients (Kd) of Ge(IV) on the anion exchange (Dowex 1x8) and cation exchange (Dowex 50x8) resins in various ethanedioic and hydrochloric acid solutions were determined. For each ion exchange resin, four series of measurements were carried out, in which the concentration of oxalic acid was fixed (0.001 M, 0.003 M, 0.005 M, 0.01 M), and the concentrations of hydrochloric acid ranged from 0 to 3 M. Based on the distribution coefficients, the chemical scheme of the radionuclide generator 68Ge -> 68Ga has been developed. The chemical system is based on the anion exchange resin Dowex 1x8 and mixture of 0.005 M C2H2O4 / 0.33 M HCl. Several types of the generators with direct and reverse mode of elution were tested and the optimal scheme was determined. Elution of the generators was performed once a day with 8 ml of 0.005 M C2H2O4 / 0.33 M HCl solution. The 68Ga yield and the 68Ge breakthrough are comparable for all the systems.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Bulletin of Kazakh National University

ISSN

1563-0331

e-ISSN

2312-7554

Svazek periodika

2018

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

KZ - Republika Kazachstán

Počet stran výsledku

7

Strana od-do

20-26

Kód UT WoS článku

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EID výsledku v databázi Scopus

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