DOTA DECORATED HYDROXYAPATITE NANOPARTICLES LABELLED WITH 68Ga

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F18%3A00323742" target="_blank" >RIV/68407700:21340/18:00323742 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

DOTA DECORATED HYDROXYAPATITE NANOPARTICLES LABELLED WITH 68Ga

Popis výsledku v původním jazyce

Hydroxyapatite nanoparticles (HAp-NPs) are widely used in medicine because of their biocompatibility and stability in various media [1]. The HAp-NPs also belong to promising drug carrier systems for medicinal radionuclides such as Ga-68 as the part of multipurpose theranostic system. Diagnosis and therapy of some diseases is expected to be very accurate and beneficial. Labelling was carried out with pristine NPs and NPs decorated with selected ligands: DOTA, NOTA, TETA and TRAP (0.05 mg). Best result was obtained in a procedure when the 68Ga was added to the NPs dispersion in the DOTA ligand. Further experiments have shown that uptake kinetics is quite fast (over 90% yield within 5 minutes) and good stability of 68Ga-DOTA-HAp-NPs nanoconstruct in a physiological saline (more than 95 % of activity remained bound to the NPs in 4 hours).

Název v anglickém jazyce

DOTA DECORATED HYDROXYAPATITE NANOPARTICLES LABELLED WITH 68Ga

Popis výsledku anglicky

Hydroxyapatite nanoparticles (HAp-NPs) are widely used in medicine because of their biocompatibility and stability in various media [1]. The HAp-NPs also belong to promising drug carrier systems for medicinal radionuclides such as Ga-68 as the part of multipurpose theranostic system. Diagnosis and therapy of some diseases is expected to be very accurate and beneficial. Labelling was carried out with pristine NPs and NPs decorated with selected ligands: DOTA, NOTA, TETA and TRAP (0.05 mg). Best result was obtained in a procedure when the 68Ga was added to the NPs dispersion in the DOTA ligand. Further experiments have shown that uptake kinetics is quite fast (over 90% yield within 5 minutes) and good stability of 68Ga-DOTA-HAp-NPs nanoconstruct in a physiological saline (more than 95 % of activity remained bound to the NPs in 4 hours).

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů