Small-scale production of 161Tb for preclinical studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F23%3A00370438" target="_blank" >RIV/68407700:21340/23:00370438 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00259-023-06333-x" target="_blank" >https://link.springer.com/article/10.1007/s00259-023-06333-x</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Small-scale production of 161Tb for preclinical studies

Popis výsledku v původním jazyce

Terbium-161 is promising theranostic radionuclide thanks to its good decay characteristics, i.e. its half-life of 6,89 d and emission of soft β- particles with Eβmax of 593 keV together with several conversion and Auger-Meitner secondary low energy electrons that contribute to the enhancement of the therapeutic effect. It also emits γ radiation with energy 74 keV, suitable for SPECT imaging and therapy follow-up monitoring. The most convenient method for no-carrier-added 161Tb production is the nuclear reactor irradiation of enriched 160Gd using indirect route of 160Gd(n,γ)161Gd=>161Tb. The 161Tb was produced by the irradiation of highly enriched 160Gd (98,6 %) in the form of oxide or nitrate in the nuclear reactor LVR-15 (CV Řež, Czech rep.). The separation was performed using cation exchange chromatography on Dowex 50Wx8 resin with α-hydroxyisobutyric acid as co-eluent. Different dimensions of glass chromatography columns were tested with respect to the target mass. The finally separated and purified 161Tb was formulated to 0.05 M HCl in the form of terbium chloride. The radionuclidic purity of prepared 161Tb was verified by gamma spectrometry on an HPGe detector, chemical purity was estimated by ICP-MS. Further, the labelling test with DOTA was performed to assess overall sample purity. The 161Tb was successfully prepared with the highest amounts of up to 13 GBq and the highest activities of purified 161Tb samples reached almost 12 GBq (EOB)

Název v anglickém jazyce

Small-scale production of 161Tb for preclinical studies

Popis výsledku anglicky

Terbium-161 is promising theranostic radionuclide thanks to its good decay characteristics, i.e. its half-life of 6,89 d and emission of soft β- particles with Eβmax of 593 keV together with several conversion and Auger-Meitner secondary low energy electrons that contribute to the enhancement of the therapeutic effect. It also emits γ radiation with energy 74 keV, suitable for SPECT imaging and therapy follow-up monitoring. The most convenient method for no-carrier-added 161Tb production is the nuclear reactor irradiation of enriched 160Gd using indirect route of 160Gd(n,γ)161Gd=>161Tb. The 161Tb was produced by the irradiation of highly enriched 160Gd (98,6 %) in the form of oxide or nitrate in the nuclear reactor LVR-15 (CV Řež, Czech rep.). The separation was performed using cation exchange chromatography on Dowex 50Wx8 resin with α-hydroxyisobutyric acid as co-eluent. Different dimensions of glass chromatography columns were tested with respect to the target mass. The finally separated and purified 161Tb was formulated to 0.05 M HCl in the form of terbium chloride. The radionuclidic purity of prepared 161Tb was verified by gamma spectrometry on an HPGe detector, chemical purity was estimated by ICP-MS. Further, the labelling test with DOTA was performed to assess overall sample purity. The 161Tb was successfully prepared with the highest amounts of up to 13 GBq and the highest activities of purified 161Tb samples reached almost 12 GBq (EOB)

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/TO01000074" target="_blank" >TO01000074: Účinná terapie nádorových onemocnění nízkoenergetickými elektrony terbia-161.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů