The effect of chitosan and chitooligosaccharides on the fecal microbiota of healthy rats.
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F11%3A00192486" target="_blank" >RIV/68407700:21460/11:00192486 - isvavai.cz</a>
Výsledek na webu
<a href="http://imbm.fbmi.cvut.cz/soubory/sbornik.pdf" target="_blank" >http://imbm.fbmi.cvut.cz/soubory/sbornik.pdf</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The effect of chitosan and chitooligosaccharides on the fecal microbiota of healthy rats.
Popis výsledku v původním jazyce
Chitosan (CS) is a functional linear polysaccharide, which is prepared by partial N-deacetylation of chitin. Chitooligosaccharides (COS) can be produced by hydrolysis of CS. They exhibit various types of the potent biological activities useful for medical applications and health care. The changes in the bacterial population, followed by the shifts in the produced bacterial metabolites can significantly alter condition in gastrointestinal tract. In this in vivo study we modulated the changes of fecal bacteria population in healthy rats (groups: control, CS and COS) during administration of CS/COS. PCR-DGGE analysis was used to detect possible changes in bacterial population. The phylogenetic tree was also constructed. For the quantification of total andselected bacterial DNA was used real-time PCR analysis. CS/COS changed the composition of microbial ecosystem of gastrointestinal tract of healthy rats.
Název v anglickém jazyce
The effect of chitosan and chitooligosaccharides on the fecal microbiota of healthy rats.
Popis výsledku anglicky
Chitosan (CS) is a functional linear polysaccharide, which is prepared by partial N-deacetylation of chitin. Chitooligosaccharides (COS) can be produced by hydrolysis of CS. They exhibit various types of the potent biological activities useful for medical applications and health care. The changes in the bacterial population, followed by the shifts in the produced bacterial metabolites can significantly alter condition in gastrointestinal tract. In this in vivo study we modulated the changes of fecal bacteria population in healthy rats (groups: control, CS and COS) during administration of CS/COS. PCR-DGGE analysis was used to detect possible changes in bacterial population. The phylogenetic tree was also constructed. For the quantification of total andselected bacterial DNA was used real-time PCR analysis. CS/COS changed the composition of microbial ecosystem of gastrointestinal tract of healthy rats.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
EE - Mikrobiologie, virologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/EE.2.3.20.0092" target="_blank" >EE.2.3.20.0092: Rozvoj výzkumného týmu BIO-OPT-XUV na FBMI ČVUT</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů