What does the Tpeak-Tend interval reflect? An experimental and model study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F13%3A00212492" target="_blank" >RIV/68407700:21460/13:00212492 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pubmed/23473669" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/23473669</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelectrocard.2013.02.001" target="_blank" >10.1016/j.jelectrocard.2013.02.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

What does the Tpeak-Tend interval reflect? An experimental and model study

Popis výsledku v původním jazyce

Background It is unclear whether the Tpeak-Tend interval is an index of the transmural or the total dispersion of repolarization. Methods We examined the Tpeak-Tend interval using a computer model of the rabbit heart ventricles based on experimentally measured transmural, apicobasal, and interventricular gradients of action potential duration. Results Experimentally measured activation-recovery intervals increased from apex to base, from the left ventricle to the right ventricle, and in the apical portion of the left ventricle from epicardium to endocardium and from the right side of septum to the left side. The simulated Tpeak corresponded to the earliest end of repolarization, whereas the Tend corresponded to the latest end of repolarization. The different components of the global repolarization dispersion were discerned by simulation. Conclusions The Tpeak-T end interval corresponds to the global dispersion of repolarization with distinct contributions of the apicobasal and transmur

Název v anglickém jazyce

What does the Tpeak-Tend interval reflect? An experimental and model study

Popis výsledku anglicky

Background It is unclear whether the Tpeak-Tend interval is an index of the transmural or the total dispersion of repolarization. Methods We examined the Tpeak-Tend interval using a computer model of the rabbit heart ventricles based on experimentally measured transmural, apicobasal, and interventricular gradients of action potential duration. Results Experimentally measured activation-recovery intervals increased from apex to base, from the left ventricle to the right ventricle, and in the apical portion of the left ventricle from epicardium to endocardium and from the right side of septum to the left side. The simulated Tpeak corresponded to the earliest end of repolarization, whereas the Tend corresponded to the latest end of repolarization. The different components of the global repolarization dispersion were discerned by simulation. Conclusions The Tpeak-T end interval corresponds to the global dispersion of repolarization with distinct contributions of the apicobasal and transmur

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Electrocardiology

ISSN

0022-0736

e-ISSN

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Svazek periodika

46

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

"296.e1"-"296.e8"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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