Effects of an antioxidant agent on alterations of ventricular repolarization in a coronary artery occlusion-reperfusion experimental model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F13%3A00212501" target="_blank" >RIV/68407700:21460/13:00212501 - isvavai.cz</a>

Výsledek na webu

<a href="http://cardiologyacademicpress.com/?p=20032" target="_blank" >http://cardiologyacademicpress.com/?p=20032</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of an antioxidant agent on alterations of ventricular repolarization in a coronary artery occlusion-reperfusion experimental model

Popis výsledku v původním jazyce

BACKGROUND AND OBJECTIVE: Antioxidant agents can prevent oxidative stress and, therefore, cardiac arrhythmias. Electrophysiological mechanisms underlying antiarrhythmic action of antioxidants are not well understood. Echinochrome is an antioxidant and iron-chelating agent of natural origin. Effects of synthetic echinochrome on ischemia- and reperfusion-induced alterations of ventricular repolarization were studied in a coronary artery occlusion-reperfusion model. METHODS: Cats underwent a brief coronaryocclusion-reperfusion sequence (30 min ? 30 min). To map repolarization, activation-recovery intervals (ARIs) were measured using thirty to forty-one left ventricular unipolar extracellular electrograms. Echinochrome was administered intravenously in adose of 1 mg/kg 5 min before occlusion and/or 5 min before reperfusion. RESULTS: Echinochrome raised the central aortic pressure and did not affect ARIs in non-ischemic myocardium. When echinochrome was administered before reperfusion, re

Název v anglickém jazyce

Effects of an antioxidant agent on alterations of ventricular repolarization in a coronary artery occlusion-reperfusion experimental model

Popis výsledku anglicky

BACKGROUND AND OBJECTIVE: Antioxidant agents can prevent oxidative stress and, therefore, cardiac arrhythmias. Electrophysiological mechanisms underlying antiarrhythmic action of antioxidants are not well understood. Echinochrome is an antioxidant and iron-chelating agent of natural origin. Effects of synthetic echinochrome on ischemia- and reperfusion-induced alterations of ventricular repolarization were studied in a coronary artery occlusion-reperfusion model. METHODS: Cats underwent a brief coronaryocclusion-reperfusion sequence (30 min ? 30 min). To map repolarization, activation-recovery intervals (ARIs) were measured using thirty to forty-one left ventricular unipolar extracellular electrograms. Echinochrome was administered intravenously in adose of 1 mg/kg 5 min before occlusion and/or 5 min before reperfusion. RESULTS: Echinochrome raised the central aortic pressure and did not affect ARIs in non-ischemic myocardium. When echinochrome was administered before reperfusion, re

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental & Clinical Cardiology

ISSN

1205-6626

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000340731600007

EID výsledku v databázi Scopus

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