Esmolol abolishes repolarization gradients in diabetic rabbit hearts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F14%3A00219802" target="_blank" >RIV/68407700:21460/14:00219802 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Esmolol abolishes repolarization gradients in diabetic rabbit hearts

Popis výsledku v původním jazyce

The study investigated the contribution of abnormal sympathetic influences to the changes of ventricular repolarization pattern in rabbits with short-term diabetes. The experiments were performed in anaesthetized 11 alloxan-induced (4-5 weeks) diabetic and 13 healthy rabbits. Unipolar electrograms were recorded from 64 ventricular epicardial leads prior to and after the injection of beta1-blocker esmolol (0.5 mg/kg, i.v.). Activation times (dV/dt min during QRS), end of repolarization times (dV/dt max during ST-T) and their differences (activationrecovery intervals) were determined. In diabetic rabbits, activation-recovery intervals were longer in the left ventricular apex than in its base, on the right ventricular free wall than on the left ventricular free wall, and on the anterior surface than on the posterior surface (P<0.05). Injection of esmolol in control group resulted in the development of the significant apicobasal difference in repolarization durations (P<0.05). In the diabe

Název v anglickém jazyce

Esmolol abolishes repolarization gradients in diabetic rabbit hearts

Popis výsledku anglicky

The study investigated the contribution of abnormal sympathetic influences to the changes of ventricular repolarization pattern in rabbits with short-term diabetes. The experiments were performed in anaesthetized 11 alloxan-induced (4-5 weeks) diabetic and 13 healthy rabbits. Unipolar electrograms were recorded from 64 ventricular epicardial leads prior to and after the injection of beta1-blocker esmolol (0.5 mg/kg, i.v.). Activation times (dV/dt min during QRS), end of repolarization times (dV/dt max during ST-T) and their differences (activationrecovery intervals) were determined. In diabetic rabbits, activation-recovery intervals were longer in the left ventricular apex than in its base, on the right ventricular free wall than on the left ventricular free wall, and on the anterior surface than on the posterior surface (P<0.05). Injection of esmolol in control group resulted in the development of the significant apicobasal difference in repolarization durations (P<0.05). In the diabe

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental & Clinical Cardiology

ISSN

1205-6626

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

14

Strana od-do

3780-3793

Kód UT WoS článku

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EID výsledku v databázi Scopus

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