Study of the DBS STN Effect on Parkinson's Disease Finger Tapping Using NIRS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F16%3A00307097" target="_blank" >RIV/68407700:21460/16:00307097 - isvavai.cz</a>

Výsledek na webu

<a href="http://hb2016.fbmi.cvut.cz" target="_blank" >http://hb2016.fbmi.cvut.cz</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of the DBS STN Effect on Parkinson's Disease Finger Tapping Using NIRS

Popis výsledku v původním jazyce

Near-infrared spectroscopy (NIRS) of brain function employs low-energy optical radiation for measuring absorption changes in sub-surface tissues, in order to infer local concentration changes of oxy- and de-oxyhemoglobin as correlates of functional brain activity. To achieve brain activity spatial mapping, arrays of multiple source-detector pairs are placed over the area of interest. The aim of this study is to evaluate differences in brain activity, caused by level of deep brain stimulation of subthalamic nucleus (DBS STN), during finger tapping (FT) task of patients with Parkinson's disease (PD). DBS STN is a procedure used to treat PD symptoms (essential tremor and dystonia). Brain activity of specific area is represented by extracted value parameter from NIRS signal. Individual measurements were done at the Department of Neurology, First Medical Faculty in Prague. Clinical set consisted of left and right hand FT examination for every patient (N = 9). All measurements were performed on NIRSport device, comprising 7 sources and 8 detectors. Differences in activities in the individual areas of the brain during stimulation and without stimulation were tested by the nonparametric Wilcoxon paired test. Statistically significant differences (at alpha = 0,05) of FT right hand were reached in the primary motor cortex (M1), in the supplementary motor area (SMA) and in the premotor cortex (PM). Therefore, in fields related to planning and executing motion.

Název v anglickém jazyce

Study of the DBS STN Effect on Parkinson's Disease Finger Tapping Using NIRS

Popis výsledku anglicky

Near-infrared spectroscopy (NIRS) of brain function employs low-energy optical radiation for measuring absorption changes in sub-surface tissues, in order to infer local concentration changes of oxy- and de-oxyhemoglobin as correlates of functional brain activity. To achieve brain activity spatial mapping, arrays of multiple source-detector pairs are placed over the area of interest. The aim of this study is to evaluate differences in brain activity, caused by level of deep brain stimulation of subthalamic nucleus (DBS STN), during finger tapping (FT) task of patients with Parkinson's disease (PD). DBS STN is a procedure used to treat PD symptoms (essential tremor and dystonia). Brain activity of specific area is represented by extracted value parameter from NIRS signal. Individual measurements were done at the Department of Neurology, First Medical Faculty in Prague. Clinical set consisted of left and right hand FT examination for every patient (N = 9). All measurements were performed on NIRSport device, comprising 7 sources and 8 detectors. Differences in activities in the individual areas of the brain during stimulation and without stimulation were tested by the nonparametric Wilcoxon paired test. Statistically significant differences (at alpha = 0,05) of FT right hand were reached in the primary motor cortex (M1), in the supplementary motor area (SMA) and in the premotor cortex (PM). Therefore, in fields related to planning and executing motion.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

<a href="/cs/project/NV16-28119A" target="_blank" >NV16-28119A: Analýza pohybových poruch pro studium mechanismů postižení u extrapyramidových onemocnění pomocí „motion capture“ kamerových systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

16th Conference on Human Biomechanics 2016 – Conference proceedings

ISBN

9788001060391

ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

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Název nakladatele

Faculty of biomedical engineering, Department of Natural sciences

Místo vydání

Kladno

Místo konání akce

Kladno

Datum konání akce

7. 11. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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