Microelectrode Neuronal Activity Biomarker of the Internal Globus Pallidus in Dystonia Correlates with Long-term Neuromodulation Effects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00326023" target="_blank" >RIV/68407700:21460/18:00326023 - isvavai.cz</a>

Výsledek na webu

<a href="https://ieeexplore.ieee.org/document/8531122" target="_blank" >https://ieeexplore.ieee.org/document/8531122</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/HealthCom.2018.8531122" target="_blank" >10.1109/HealthCom.2018.8531122</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microelectrode Neuronal Activity Biomarker of the Internal Globus Pallidus in Dystonia Correlates with Long-term Neuromodulation Effects

Popis výsledku v původním jazyce

Deep brain stimulation (DBS) of the human basal ganglia is an important therapeutical method of alleviating the symptoms of dystonias of various aetiology. Accurate targeting of the permanent stimulation electrode into the Globus Pallidus internus (GPi) is key to positive long-term effects. The suitability of the location is preoperatively assessed by microelectrodes that register single-unit neuronal activity. The aim of this paper is to analyse electrophysiological recordings of patient's neuronal activity with a focus on the identification of markers relevant to the patient's clinical state. Specific biomarkers may help determine targets and patient-specific protocols for neuromodulation therapy. In this study, 13 patients chronically treated with double-sided DBS GPi were examined with microrecordings. The signal (24 kHz) processing included bandpass filtering (0.5-5 kHz), automated detection of the artefacts, and feature extraction. The results show that the GPi was distinguished from its vicinity with p<0.001 and 3 machine learning models AUCs had an accuracy of higher than 0.87. The observed biomarker, Hjort Mobility, additionally correlated with the long-term neuromodulation effect (rho = -0.4; p<0.05). We assume that this research will contribute to a better understanding of the underlying mechanisms of DBS GPi.

Název v anglickém jazyce

Microelectrode Neuronal Activity Biomarker of the Internal Globus Pallidus in Dystonia Correlates with Long-term Neuromodulation Effects

Popis výsledku anglicky

Deep brain stimulation (DBS) of the human basal ganglia is an important therapeutical method of alleviating the symptoms of dystonias of various aetiology. Accurate targeting of the permanent stimulation electrode into the Globus Pallidus internus (GPi) is key to positive long-term effects. The suitability of the location is preoperatively assessed by microelectrodes that register single-unit neuronal activity. The aim of this paper is to analyse electrophysiological recordings of patient's neuronal activity with a focus on the identification of markers relevant to the patient's clinical state. Specific biomarkers may help determine targets and patient-specific protocols for neuromodulation therapy. In this study, 13 patients chronically treated with double-sided DBS GPi were examined with microrecordings. The signal (24 kHz) processing included bandpass filtering (0.5-5 kHz), automated detection of the artefacts, and feature extraction. The results show that the GPi was distinguished from its vicinity with p<0.001 and 3 machine learning models AUCs had an accuracy of higher than 0.87. The observed biomarker, Hjort Mobility, additionally correlated with the long-term neuromodulation effect (rho = -0.4; p<0.05). We assume that this research will contribute to a better understanding of the underlying mechanisms of DBS GPi.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

2018 IEEE 20th International Conference on e-Health Networking, Applications and Services (Healthcom)

ISBN

978-1-5386-4294-8

ISSN

—

e-ISSN

—

Počet stran výsledku

6

Strana od-do

—

Název nakladatele

IEEE

Místo vydání

Piscataway

Místo konání akce

Ostrava

Datum konání akce

17. 9. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—