The Accuracy of Noninvasive Localization of Ectopic Focus: Simulation Study of the Impact of Focus Position and Used ECG Leads
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00329831" target="_blank" >RIV/68407700:21460/18:00329831 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.jelectrocard.2018.10.010" target="_blank" >http://dx.doi.org/10.1016/j.jelectrocard.2018.10.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jelectrocard.2018.10.010" target="_blank" >10.1016/j.jelectrocard.2018.10.010</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Accuracy of Noninvasive Localization of Ectopic Focus: Simulation Study of the Impact of Focus Position and Used ECG Leads
Popis výsledku v původním jazyce
Introduction: Noninvasive preoperative localization of the premature ventricular contraction (PVC) focus can significantly decrease the time of the electrophysiological study and improve the radiofrequency ablation outcome. The impact of the focus position and configuration of measured ECG leads on the focus localization error was studied. Methods: ECGSim software was used to simulate PVCs starting in both ventricles with ectopic foci located in anterior, lateral, posterior, and septal segments. In each segment, fifteen foci were simulated: 5 epicardial, 5 endocardial and 5 placed near the valve. For each simulation, cardiac electric generator represented by an equivalent double layer was used to solve the forward problem of electrocardiography and to calculate body surface potentials (BSPs) in three lead configurations: 64 Nijmegen leads, 192 leads in 16x12 grid, and 300 leads in the torso model nodes. Each focus was then localized by solving the inverse problem with a single dipole as the equivalent cardiac generator. Integral BSPs from the initial 5 ms of the premature activation and inhomogeneous torso model including body surface, lungs, and ventricular cavities were used in the computations. The localization error (LE) was defined as the distance between the location of the simulated focus and the location found by the inverse solution. Results: The LE varied from 0.36 to 33.52 mm. For 192 and 300 leads the LEs were similar, with slightly higher values for foci in the left ventricle. For 64 leads, the LEs were much larger, with significantly higher values for foci in the right ventricle (p<0.05). Conclusions: The LE was dependent on both, position of the ectopic focus and the used ECG leads. Increased number of leads above 192 did not improve the accuracy of the inverse localization. The use of 64 non-uniformly distributed leads resulted in higher LEs and increased impact of the focus position.
Název v anglickém jazyce
The Accuracy of Noninvasive Localization of Ectopic Focus: Simulation Study of the Impact of Focus Position and Used ECG Leads
Popis výsledku anglicky
Introduction: Noninvasive preoperative localization of the premature ventricular contraction (PVC) focus can significantly decrease the time of the electrophysiological study and improve the radiofrequency ablation outcome. The impact of the focus position and configuration of measured ECG leads on the focus localization error was studied. Methods: ECGSim software was used to simulate PVCs starting in both ventricles with ectopic foci located in anterior, lateral, posterior, and septal segments. In each segment, fifteen foci were simulated: 5 epicardial, 5 endocardial and 5 placed near the valve. For each simulation, cardiac electric generator represented by an equivalent double layer was used to solve the forward problem of electrocardiography and to calculate body surface potentials (BSPs) in three lead configurations: 64 Nijmegen leads, 192 leads in 16x12 grid, and 300 leads in the torso model nodes. Each focus was then localized by solving the inverse problem with a single dipole as the equivalent cardiac generator. Integral BSPs from the initial 5 ms of the premature activation and inhomogeneous torso model including body surface, lungs, and ventricular cavities were used in the computations. The localization error (LE) was defined as the distance between the location of the simulated focus and the location found by the inverse solution. Results: The LE varied from 0.36 to 33.52 mm. For 192 and 300 leads the LEs were similar, with slightly higher values for foci in the left ventricle. For 64 leads, the LEs were much larger, with significantly higher values for foci in the right ventricle (p<0.05). Conclusions: The LE was dependent on both, position of the ectopic focus and the used ECG leads. Increased number of leads above 192 did not improve the accuracy of the inverse localization. The use of 64 non-uniformly distributed leads resulted in higher LEs and increased impact of the focus position.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
30201 - Cardiac and Cardiovascular systems
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů